Novel hydroxyapatite (HA) dual-scaffold with ultra-high porosity, high surface area, and compressive strength

In Kook Jun, Young-Hag Koh, Su H. Lee, Hyoun E. Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel scaffold designed for tissue engineering applications, which we refer to as a "dual-scaffold" because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85%), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume18
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

Fingerprint

Compressive Strength
compressive strength
Porosity
Durapatite
Hydroxyapatite
Scaffolds
Compressive strength
Graphite
porosity
Rapid prototyping
rapid prototyping
graphite
Tissue Engineering
Scaffolds (biology)
Pore structure
Tissue engineering
tissue engineering
Hot Temperature
Air
preserving

ASJC Scopus subject areas

  • Biophysics
  • Chemical Engineering(all)
  • Bioengineering

Cite this

Novel hydroxyapatite (HA) dual-scaffold with ultra-high porosity, high surface area, and compressive strength. / Jun, In Kook; Koh, Young-Hag; Lee, Su H.; Kim, Hyoun E.

In: Journal of Materials Science: Materials in Medicine, Vol. 18, No. 6, 01.06.2007, p. 1071-1077.

Research output: Contribution to journalArticle

@article{c423f2f1c56d440db5576c314974bc0c,
title = "Novel hydroxyapatite (HA) dual-scaffold with ultra-high porosity, high surface area, and compressive strength",
abstract = "A novel scaffold designed for tissue engineering applications, which we refer to as a {"}dual-scaffold{"} because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85{\%}), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.",
author = "Jun, {In Kook} and Young-Hag Koh and Lee, {Su H.} and Kim, {Hyoun E.}",
year = "2007",
month = "6",
day = "1",
doi = "10.1007/s10856-007-0137-y",
language = "English",
volume = "18",
pages = "1071--1077",
journal = "Journal of Materials Science: Materials in Electronics",
issn = "0957-4522",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Novel hydroxyapatite (HA) dual-scaffold with ultra-high porosity, high surface area, and compressive strength

AU - Jun, In Kook

AU - Koh, Young-Hag

AU - Lee, Su H.

AU - Kim, Hyoun E.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - A novel scaffold designed for tissue engineering applications, which we refer to as a "dual-scaffold" because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85%), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.

AB - A novel scaffold designed for tissue engineering applications, which we refer to as a "dual-scaffold" because its structure consists of two interlaced three-dimensional (3-D) hydroxyapatite (HA) networks, was fabricated using a combination of the rapid prototyping (RP) method and dip-coating process. To accomplish this, a graphite network acting as a template was prepared using the RP method and then uniformly dip-coated with HA slurry. The resultant sample was then heat-treated at 1250°C for 3 h in air to remove the graphite network and consolidate the HA networks. An additional 3-D channel was formed by removing the graphite network, while preserving the pre-existing channel. The unique structure of the dual-scaffold endows it with unprecedented features, such as ultra-high porosity (>85%), a high surface area and high compressive strength, as well as a tightly controlled pore structure. In addition, an excellent cellular response was observed to the fabricated HA dual-scaffold.

UR - http://www.scopus.com/inward/record.url?scp=34249029038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249029038&partnerID=8YFLogxK

U2 - 10.1007/s10856-007-0137-y

DO - 10.1007/s10856-007-0137-y

M3 - Article

C2 - 17268870

AN - SCOPUS:34249029038

VL - 18

SP - 1071

EP - 1077

JO - Journal of Materials Science: Materials in Electronics

JF - Journal of Materials Science: Materials in Electronics

SN - 0957-4522

IS - 6

ER -