Novel measurement of pressure inside a compliant vascular scaffold of PLCL

Hun Lee, Sang Hoon Kim, Young Mee Jung, Jong Hoon Chung, Sang Heon Kim, Soo Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dynamic environment, such as high pressure, shear force and cyclic beating, is the properties of the human artery. To overcome this harsh environment, scaffolds for human artery need high compliance and high burst strength. Bioreactor system has been developed to measure the mechanical properties, such as compliance and burst strength, of vascular scaffolds. To mimic the hemodynamic environment, we have designed a pulsatile bioreactor system. In particular, fluid mechanical theories and equations were applied to measure the real pressure inside vascular scaffolds, which characterize the compliance and strength of the scaffolds. The bioreactor system was used to measure the compliance of poly(L-lactide-co-ε-caprolactone) (PLCL), an elastic polymer, scaffolds. The compliance of a PLCL scaffold in 80∼120 mmHg was 0.753 (%mm/100 mmHg). The compliance of a PLCL scaffold ranged 0.722 to 0.989(%mm/100 mmHg). The possibility of measuring pressure inside vascular scaffolds in real time in vitro will provide the inspiration of enhancing properties of scaffold and will improve our investigation on the scaffold in vascular processes.

Original languageEnglish
Pages (from-to)298-308
Number of pages11
JournalTissue Engineering and Regenerative Medicine
Volume7
Issue number3
Publication statusPublished - 2010 May 1
Externally publishedYes

Fingerprint

Scaffolds
Compliance
Blood Vessels
Pressure
Bioreactors
Arteries
Polymers
Hemodynamics
Scaffolds (biology)
Mechanical properties
Fluids

Keywords

  • Bioreactor
  • Compliance
  • PLCL
  • Scaffold
  • Tissue enginering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Lee, H., Kim, S. H., Jung, Y. M., Chung, J. H., Kim, S. H., & Kim, S. H. (2010). Novel measurement of pressure inside a compliant vascular scaffold of PLCL. Tissue Engineering and Regenerative Medicine, 7(3), 298-308.

Novel measurement of pressure inside a compliant vascular scaffold of PLCL. / Lee, Hun; Kim, Sang Hoon; Jung, Young Mee; Chung, Jong Hoon; Kim, Sang Heon; Kim, Soo Hyun.

In: Tissue Engineering and Regenerative Medicine, Vol. 7, No. 3, 01.05.2010, p. 298-308.

Research output: Contribution to journalArticle

Lee, H, Kim, SH, Jung, YM, Chung, JH, Kim, SH & Kim, SH 2010, 'Novel measurement of pressure inside a compliant vascular scaffold of PLCL', Tissue Engineering and Regenerative Medicine, vol. 7, no. 3, pp. 298-308.
Lee, Hun ; Kim, Sang Hoon ; Jung, Young Mee ; Chung, Jong Hoon ; Kim, Sang Heon ; Kim, Soo Hyun. / Novel measurement of pressure inside a compliant vascular scaffold of PLCL. In: Tissue Engineering and Regenerative Medicine. 2010 ; Vol. 7, No. 3. pp. 298-308.
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