TY - JOUR
T1 - Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea
AU - Lee, Seung Ho
AU - No, Jin Sun
AU - Kim, Kijin
AU - Budhathoki, Shailesh
AU - Park, Kyungmin
AU - Lee, Geum Young
AU - Cho, Seungchan
AU - Kim, Bong Hyun
AU - Cho, Seunghee
AU - Kim, Jongwoo
AU - Lee, Jingyeong
AU - Cho, Seung Hye
AU - Kim, Heung Chul
AU - Klein, Terry A.
AU - Uhm, Chang Sub
AU - Kim, Won Keun
AU - Song, Jin Won
N1 - Funding Information:
We thank Su-Am Kim and Hyebin Jeong for collecting wild small mammals and describing a figure, respectively. This research was supported by Basic Research Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Education (NRF-2019R1I1A2A01060902). In addition, this work was supported by the Agency for Defense Development (UE202026GD). Partial funding was provided by the Armed Forces Health Surveillance Division Global Emerging Infections Surveillance Branch (GEIS), ProMIS ID P0039_18_ME. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. Authors, as employees of the U.S. Government (TAK, HCK), conducted the work as part of their official duties. Title 17 U.S.C. §105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. §101 defines a U.S. Government work is a work prepared by an employee of the U.S. Government as part of the person's official duties.
Funding Information:
We thank Su-Am Kim and Hyebin Jeong for collecting wild small mammals and describing a figure, respectively. This research was supported by Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2019R1I1A2A01060902). In addition, this work was supported by the Agency for Defense Development (UE202026GD). Partial funding was provided by the Armed Forces Health Surveillance Division Global Emerging Infections Surveillance Branch (GEIS), ProMIS ID P0039_18_ME. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. Authors, as employees of the U.S. Government (TAK, HCK), conducted the work as part of their official duties. Title 17 U.S.C. §105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. §101 defines a U.S. Government work is a work prepared by an employee of the U.S. Government as part of the person's official duties.
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
AB - Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
KW - Apodemus agrarius
KW - Paju Apodemus paramyxovirus 1
KW - Paju Apodemus paramyxovirus 2
KW - Phylogenetic diversity
KW - Rodent paramyxovirus
UR - http://www.scopus.com/inward/record.url?scp=85109672951&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2021.06.011
DO - 10.1016/j.virol.2021.06.011
M3 - Article
C2 - 34256243
AN - SCOPUS:85109672951
SN - 0042-6822
VL - 562
SP - 40
EP - 49
JO - Virology
JF - Virology
ER -
