Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea

Seung Ho Lee, Jin Sun No, Kijin Kim, Shailesh Budhathoki, Kyungmin Park, Geum Young Lee, Seungchan Cho, Bong Hyun Kim, Seunghee Cho, Jongwoo Kim, Jingyeong Lee, Seung Hye Cho, Heung Chul Kim, Terry A. Klein, Chang Sub Uhm, Won Keun Kim, Jin Won Song

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV-2). The disparity between PAPV-1 (19,716 nucleotides) and -2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and -2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.

Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalVirology
Volume562
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Apodemus agrarius
  • Paju Apodemus paramyxovirus 1
  • Paju Apodemus paramyxovirus 2
  • Phylogenetic diversity
  • Rodent paramyxovirus

ASJC Scopus subject areas

  • Virology

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