Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells

Sang Hoon Kim, Jae Ho Song, Min Ji Kim, Mun Gu Song, Angel A. Ku, Sourav Bandyopadhyay, Frank McCormick, Sung Eun Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention.

Original languageEnglish
Article number831
JournalMetabolites
Volume12
Issue number9
DOIs
Publication statusPublished - 2022 Sep

Keywords

  • cancer metabolism
  • Informer set library screening
  • macropinocytosis
  • nutrient scavenging
  • pancreatic cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology

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