Abstract
This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (∼451×305 μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353 kPa and compressive strength of~31 kPa at a porosity of~95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 265-268 |
| Number of pages | 4 |
| Journal | Materials Letters |
| Volume | 143 |
| DOIs | |
| Publication status | Published - 2015 Mar 15 |
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Keywords
- Biomaterials
- Biomimetic
- Microstructure
- Polymers
- Porous materials
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering
- Mechanics of Materials
Cite this
Novel self-assembly-induced 3D plotting for macro/nano-porous collagen scaffolds comprised of nanofibrous collagen filaments. / Shin, Kwan Ha; Kim, Jong Woo; Koh, Young-Hag; Kim, Hyoun Ee.
In: Materials Letters, Vol. 143, 15.03.2015, p. 265-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel self-assembly-induced 3D plotting for macro/nano-porous collagen scaffolds comprised of nanofibrous collagen filaments
AU - Shin, Kwan Ha
AU - Kim, Jong Woo
AU - Koh, Young-Hag
AU - Kim, Hyoun Ee
PY - 2015/3/15
Y1 - 2015/3/15
N2 - This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (∼451×305 μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353 kPa and compressive strength of~31 kPa at a porosity of~95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.
AB - This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (∼451×305 μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353 kPa and compressive strength of~31 kPa at a porosity of~95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.
KW - Biomaterials
KW - Biomimetic
KW - Microstructure
KW - Polymers
KW - Porous materials
UR - http://www.scopus.com/inward/record.url?scp=84921326231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921326231&partnerID=8YFLogxK
U2 - 10.1016/j.matlet.2014.12.119
DO - 10.1016/j.matlet.2014.12.119
M3 - Article
AN - SCOPUS:84921326231
VL - 143
SP - 265
EP - 268
JO - Materials Letters
JF - Materials Letters
SN - 0167-577X
ER -