Abstract
This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (∼451×305 μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353 kPa and compressive strength of~31 kPa at a porosity of~95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.
Original language | English |
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Pages (from-to) | 265-268 |
Number of pages | 4 |
Journal | Materials Letters |
Volume | 143 |
DOIs | |
Publication status | Published - 2015 Mar 15 |
Keywords
- Biomaterials
- Biomimetic
- Microstructure
- Polymers
- Porous materials
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering