Novel self-assembly-induced 3D plotting for macro/nano-porous collagen scaffolds comprised of nanofibrous collagen filaments

Kwan Ha Shin, Jong Woo Kim, Young-Hag Koh, Hyoun Ee Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study proposes self-assembly-induced 3D plotting as an innovative solid freeform fabrication (SFF) technique for the production of macro/nano-porous collagen scaffolds, particularly comprised of nanofibrous collagen filaments. In this technique, collagen filaments deposited in a coagulation bath could be effectively gelled through the self-assembly of collagen molecules into fibrils, accordingly, enabling the 3-dimensional deposition of collagen filaments with a collagen nanofiber network. The unique macro/nano-structure could be structurally stabilized by dehydration process coupled with chemical cross-linking. The porous collagen scaffolds produced had 3-dimensionally interconnected macropores (∼451×305 μm in pore width) separated by nanoprous collagen filaments. In addition, the macro/nano-porous collagen scaffolds showed the tensile strength of~353 kPa and compressive strength of~31 kPa at a porosity of~95 vol% and excellent in vitro biocompatibility, assessed using pre-osteoblast MC3T3-E1 cells.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalMaterials Letters
Volume143
DOIs
Publication statusPublished - 2015 Mar 15

Keywords

  • Biomaterials
  • Biomimetic
  • Microstructure
  • Polymers
  • Porous materials

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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