Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

Moon Kook Jeon, Ju L. Hyun, Deok-Chan Ha, Young D. Gong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five-or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.

Original languageEnglish
Pages (from-to)1431-1435
Number of pages5
JournalSynlett
Issue number9
DOIs
Publication statusPublished - 2007 Jun 1

Fingerprint

Condensation reactions
Polymers
Derivatives
Experiments
4-hydroxyquinolin-2(1H)-one
anthranilic acid

Keywords

  • Combinatorial chemistry
  • Cyclative cleavage
  • Dieckmann condensation
  • Quinolinone
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library. / Jeon, Moon Kook; Hyun, Ju L.; Ha, Deok-Chan; Gong, Young D.

In: Synlett, No. 9, 01.06.2007, p. 1431-1435.

Research output: Contribution to journalArticle

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