Nucleotide sequence and phylogenetic analysis of M and L segment of soochong virus

Ju Kim Eun, Sil Moon Sung, Ki-Joon Song, Jin Won Song, Sook Park Kwang, Ju Baek Luck

Research output: Contribution to journalArticle

Abstract

Hantaan virus (HTNV) and Seoul virus (SEOV) have mainly been known as the cause of hemorrhagic fever with renal syndrome (HFRS) in Korea since HTNV has been isolated from Korean field mouse, Apodemus agrarius in 1976 and SEOV has been isolated from Rattus norvegicus in 1980. Soochong virus-1, -2, -3, -4 (SOOVs) were isolated from lung tissues of four Apodemus peninsulae captured on August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. Apodemus peninsulae is the second-most dominant field rodent species found throughout Korea. To determine phylogenetic analysis of SOOVs, we entirely identified nucleotide sequences of M and L segments. The length of M segment was 3,615 bp and L segment was 6,533 bp. SOOVs were diverged from HTNV by 22.7-23.3% and SEOV by 36.3-37.2%, in M segment. In addition, L segment was diverged from HTNV by 21.8-22.0% and SEOV by 30.3-30.5%. SOOVs sequence compared with Amur virus (AMRV) in M segment showed that SOOVs were different with AMRV about 14.6-16.2% in nucleotide sequences. Neighbor-joining phylogenetic analysis based on entire sequences of the M and L segment indicated that the SOOVs sequences present a separate lineage with HTNV, SEOV and AMRV. SOOVs constituted an individual cluster on the phylogenetic tree and they composed a phylogenic lineage separately. According to these data, SOOVs could be classified as a new hantavirus.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalJournal of Bacteriology and Virology
Volume37
Issue number2
Publication statusPublished - 2007 Dec 1

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Sequence Analysis
Seoul virus
Hantaan virus
Viruses
Murinae
Firearms
Korea
Hantavirus
Hemorrhagic Fever with Renal Syndrome
Rodentia
Lung

Keywords

  • Apodemus peninsulae
  • Hantavirus
  • Soochong virus

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology

Cite this

Nucleotide sequence and phylogenetic analysis of M and L segment of soochong virus. / Eun, Ju Kim; Sung, Sil Moon; Song, Ki-Joon; Song, Jin Won; Kwang, Sook Park; Luck, Ju Baek.

In: Journal of Bacteriology and Virology, Vol. 37, No. 2, 01.12.2007, p. 111-118.

Research output: Contribution to journalArticle

Eun, Ju Kim ; Sung, Sil Moon ; Song, Ki-Joon ; Song, Jin Won ; Kwang, Sook Park ; Luck, Ju Baek. / Nucleotide sequence and phylogenetic analysis of M and L segment of soochong virus. In: Journal of Bacteriology and Virology. 2007 ; Vol. 37, No. 2. pp. 111-118.
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AB - Hantaan virus (HTNV) and Seoul virus (SEOV) have mainly been known as the cause of hemorrhagic fever with renal syndrome (HFRS) in Korea since HTNV has been isolated from Korean field mouse, Apodemus agrarius in 1976 and SEOV has been isolated from Rattus norvegicus in 1980. Soochong virus-1, -2, -3, -4 (SOOVs) were isolated from lung tissues of four Apodemus peninsulae captured on August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. Apodemus peninsulae is the second-most dominant field rodent species found throughout Korea. To determine phylogenetic analysis of SOOVs, we entirely identified nucleotide sequences of M and L segments. The length of M segment was 3,615 bp and L segment was 6,533 bp. SOOVs were diverged from HTNV by 22.7-23.3% and SEOV by 36.3-37.2%, in M segment. In addition, L segment was diverged from HTNV by 21.8-22.0% and SEOV by 30.3-30.5%. SOOVs sequence compared with Amur virus (AMRV) in M segment showed that SOOVs were different with AMRV about 14.6-16.2% in nucleotide sequences. Neighbor-joining phylogenetic analysis based on entire sequences of the M and L segment indicated that the SOOVs sequences present a separate lineage with HTNV, SEOV and AMRV. SOOVs constituted an individual cluster on the phylogenetic tree and they composed a phylogenic lineage separately. According to these data, SOOVs could be classified as a new hantavirus.

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