Nutrigenomic analysis of Hypolipidemic effects of Agastache rugosa essential oils in HepG2 cells and C57BL/6 mice

Hee Jin Jun, Mi Ja Chung, Kevin Dawson, Raymond L. Rodriguez, Soung Jin Houng, Sung Yun Cho, Jungae Jeun, Jin Young Kim, Kyung Heon Kim, Kuen Woo Park, Cheong Tae Kim, Sung Joon Lee

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15 Citations (Scopus)


Hypolipidemic effects of Agastache rugosa essential oil (AREO) were investigated. Gas chromatographymass spectrometry (GC-MS) analysis showed that the major compound in AREO is limonene (47%, w/w). AREO (1 mg/mL) markedly reduced low density lipoprotein (LDL) oxidation (-93%). After 3-week feeding of AREO, plasma cholesterol (-28%) and triglyceride levels (-26%) were significantly decreased in C57BL/6J mice. Mouse hepatic transcriptome profiling with oligonucleotide microarray revealed that AREO altered the expression of 2,524 genes. Notably, significant reductions in sterol regulatory element binding factor (SREBF)-1 and SREBF- 2 mRNA levels were detected. Protein expression of HMG-CoA reductase, a major target for SREBP-2, was reduced in HepG2 cells (-36%) and in mouse liver (-35 %). AREO also significantly increased mRNA (+40%) and protein (+83%) expression of the LDL receptor in HepG2 cells and mouse liver, respectively. Our findings suggest that AREO may prevent atherosclerosis via the inhibition of LDL oxidation, down-regulation of SREBF-2 and HMG-CoA reductase expression, and up-regulation of LDL receptor expression.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalFood Science and Biotechnology
Issue number1
Publication statusPublished - 2010 Feb


  • Agastache rugosa (Korean mint)
  • Cholesterol
  • Herbal essential oil
  • Hypocholesterolemic effect

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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