O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors

Kihong Lim, Hyo Ihl Chang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The novel protein modification, O-linked N-acetylglucosamine (O-GlcNAc), plays an important role in various aspects of cell regulation. Although most of nuclear transcription regulatory factors are modified by O-GlcNAc, O-GlcNAc effects on transcription remain largely undefined yet. In this study, we show that O-GlcNAc inhibits a physical interaction between Sp1 and Elf-1 transcription factors, and negatively regulates transcription of placenta and embryonic expression oncofetal protein gene (Pem). These findings suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalBiochemical and biophysical research communications
Volume380
Issue number3
DOIs
Publication statusPublished - 2009 Mar 13

Keywords

  • Elf-1
  • O-GlcNAc
  • Pem
  • Sp1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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