Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians

Ga Eun Nam; Kyung Hwan Cho; Kyungdo Han; Chul Min Kim; Byoungduck Han; Sung Jung Cho; Seung Jin Jung; Yeongkeun Kwon; Yang Hyun Kim; Do Hoon Kim; Seon Mee Kim; Youn Seon Choi; Yong Kyun Roh; Yong Gyu Park

doi:10.1038/s41416-019-0500-z

Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians

Ga Eun Nam, Kyung Hwan Cho, Kyungdo Han, Chul Min Kim, Byoungduck Han, Sung Jung Cho, Seung Jin Jung, Yeongkeun Kwon, Yang Hyun Kim, Do Hoon Kim, Seon Mee Kim, Youn Seon Choi, Yong Kyun Roh, Yong Gyu Park

* New professors

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Abstract

Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m² (1.23, 1.18–1.28), 25–29.9 kg/m² (1.41, 1.36–1.46) and ≥30 kg/m² (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	British Journal of Cancer
Volume	121
Issue number	3
DOIs	https://doi.org/10.1038/s41416-019-0500-z
Publication status	Published - 2019 Jul 30

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41416-019-0500-z

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@article{d55d7cb5a9fd4425abf71f048fb0b9ed,

title = "Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians",

abstract = "Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m2 (1.23, 1.18–1.28), 25–29.9 kg/m2 (1.41, 1.36–1.46) and ≥30 kg/m2 (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.",

author = "Nam, {Ga Eun} and Cho, {Kyung Hwan} and Kyungdo Han and Kim, {Chul Min} and Byoungduck Han and Cho, {Sung Jung} and Jung, {Seung Jin} and Yeongkeun Kwon and Kim, {Yang Hyun} and Kim, {Do Hoon} and Kim, {Seon Mee} and Choi, {Youn Seon} and Roh, {Yong Kyun} and Park, {Yong Gyu}",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Cancer Research UK.",

year = "2019",

month = jul,

day = "30",

doi = "10.1038/s41416-019-0500-z",

language = "English",

volume = "121",

pages = "271--277",

journal = "British Journal of Cancer",

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T1 - Obesity, abdominal obesity and subsequent risk of kidney cancer

T2 - a cohort study of 23.3 million East Asians

AU - Nam, Ga Eun

AU - Cho, Kyung Hwan

AU - Han, Kyungdo

AU - Kim, Chul Min

AU - Han, Byoungduck

AU - Cho, Sung Jung

AU - Jung, Seung Jin

AU - Kwon, Yeongkeun

AU - Kim, Yang Hyun

AU - Kim, Do Hoon

AU - Kim, Seon Mee

AU - Choi, Youn Seon

AU - Roh, Yong Kyun

AU - Park, Yong Gyu

PY - 2019/7/30

Y1 - 2019/7/30

N2 - Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m2 (1.23, 1.18–1.28), 25–29.9 kg/m2 (1.41, 1.36–1.46) and ≥30 kg/m2 (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

AB - Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m2 (1.23, 1.18–1.28), 25–29.9 kg/m2 (1.41, 1.36–1.46) and ≥30 kg/m2 (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

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U2 - 10.1038/s41416-019-0500-z

DO - 10.1038/s41416-019-0500-z

M3 - Article

C2 - 31231120

AN - SCOPUS:85067868413

SN - 0007-0920

VL - 121

SP - 271

EP - 277

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians

Abstract

ASJC Scopus subject areas

UN SDGs

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