Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians

Ga Eun Nam, Kyung-Hwan Cho, Kyungdo Han, Chul Min Kim, Byoungduck Han, Sung Jung Cho, Seung Jin Jung, Yeongkeun Kwon, Yang-Hyun Kim, Do-Hoon Kim, Seon Mee Kim, Youn Seon Choi, Yong Kyun Roh, Yong Gyu Park

Research output: Contribution to journalArticle

Abstract

Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m2 (1.23, 1.18–1.28), 25–29.9 kg/m2 (1.41, 1.36–1.46) and ≥30 kg/m2 (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

Original languageEnglish
JournalBritish Journal of Cancer
DOIs
Publication statusPublished - 2019 Jan 1

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Abdominal Obesity
Kidney Neoplasms
Cohort Studies
Obesity
Body Mass Index
National Health Programs
Waist Circumference
Thinness
Regression Analysis
Confidence Intervals
Incidence
Health

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Obesity, abdominal obesity and subsequent risk of kidney cancer : a cohort study of 23.3 million East Asians. / Nam, Ga Eun; Cho, Kyung-Hwan; Han, Kyungdo; Kim, Chul Min; Han, Byoungduck; Cho, Sung Jung; Jung, Seung Jin; Kwon, Yeongkeun; Kim, Yang-Hyun; Kim, Do-Hoon; Kim, Seon Mee; Choi, Youn Seon; Roh, Yong Kyun; Park, Yong Gyu.

In: British Journal of Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Nam, Ga Eun ; Cho, Kyung-Hwan ; Han, Kyungdo ; Kim, Chul Min ; Han, Byoungduck ; Cho, Sung Jung ; Jung, Seung Jin ; Kwon, Yeongkeun ; Kim, Yang-Hyun ; Kim, Do-Hoon ; Kim, Seon Mee ; Choi, Youn Seon ; Roh, Yong Kyun ; Park, Yong Gyu. / Obesity, abdominal obesity and subsequent risk of kidney cancer : a cohort study of 23.3 million East Asians. In: British Journal of Cancer. 2019.
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author = "Nam, {Ga Eun} and Kyung-Hwan Cho and Kyungdo Han and Kim, {Chul Min} and Byoungduck Han and Cho, {Sung Jung} and Jung, {Seung Jin} and Yeongkeun Kwon and Yang-Hyun Kim and Do-Hoon Kim and Kim, {Seon Mee} and Choi, {Youn Seon} and Roh, {Yong Kyun} and Park, {Yong Gyu}",
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AU - Nam, Ga Eun

AU - Cho, Kyung-Hwan

AU - Han, Kyungdo

AU - Kim, Chul Min

AU - Han, Byoungduck

AU - Cho, Sung Jung

AU - Jung, Seung Jin

AU - Kwon, Yeongkeun

AU - Kim, Yang-Hyun

AU - Kim, Do-Hoon

AU - Kim, Seon Mee

AU - Choi, Youn Seon

AU - Roh, Yong Kyun

AU - Park, Yong Gyu

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N2 - Background: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. Methods: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009–2012 and performed multivariable Cox proportional hazards regression analyses. Results: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68–0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23–24.9 kg/m2 (1.23, 1.18–1.28), 25–29.9 kg/m2 (1.41, 1.36–1.46) and ≥30 kg/m2 (1.77, 1.65–1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40–1.50). Conclusions: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.

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