Obesity and risk factors for cardiovascular disease and type 2 diabetes

Investigating the role of physical activity and sedentary behaviour in mid-life in the 1958 British cohort

Chris Power, Snehal M. Pinto Pereira, Catherine Law, Myung Ki

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: A key public health priority is to minimise obesity-related health consequences. We aim to establish whether physical activity (PA) or less sedentary behaviour ameliorate associations of obesity with biomarkers for cardiovascular disease (CVD) and type 2 diabetes. Methods: Data on obesity (33. y), PA (42. y), TV-viewing and health biomarkers (45. y) are from the 1958 British birth cohort (N= 9377). Results: Obesity was associated with an adverse biomarker profile for CVD and type 2 diabetes. For PA, men active ≥1/week had 1.09% (0.28, 1.90) lower diastolic blood pressure (DBP) than less active men; triglycerides were 2.08% (0.52, 3.64) lower per unit higher PA (on 4-point scale). TV-viewing was independently associated with several biomarkers, e.g. per unit higher TV-viewing (on 4-point scale) DBP was raised by 0.50% (0.09, 0.90) and triglycerides by 3.61% (1.58, 5.64). For both TV-viewing and PA, associations with HbA1c were greatest for the obese (pinteraction≤0.04): compared to a reference value of 5.20 HbA1c% in non-obese men viewing 0-1h/day, HbA1c% differed little for those viewing >3h/day; among obese men HbA1c% was 5.36 (5.22, 5.51) and 5.65 (5.53, 5.76), for 0-1 and >3h/day respectively. For PA in non-obese men, the reduction associated with activity ≥1/week was negligible compared to a reference value of 5.20 HbA1c% for those less active; but there was a reduction among obese men, HbA1c% was 5.50 (5.40, 5.59) vs 5.66 (5.55, 5.77) respectively. Conclusion: Reduced TV-viewing and prevention of infrequent activity have greatest beneficial associations for glucose metabolism among the obese, with benefits for other biomarkers across obese and non-obese groups.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalAtherosclerosis
Volume233
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Cardiovascular Diseases
Obesity
Exercise
Biomarkers
Blood Pressure
Reference Values
Triglycerides
Health Priorities
Health
Public Health
Parturition
Glucose

Keywords

  • Body mass index
  • Cardiovascular diseases
  • Glucose metabolism
  • Physical activity
  • Sedentary behaviour
  • TV-viewing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Obesity and risk factors for cardiovascular disease and type 2 diabetes : Investigating the role of physical activity and sedentary behaviour in mid-life in the 1958 British cohort. / Power, Chris; Pinto Pereira, Snehal M.; Law, Catherine; Ki, Myung.

In: Atherosclerosis, Vol. 233, No. 2, 01.01.2014, p. 363-369.

Research output: Contribution to journalArticle

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