Obesity is an independent predictor of biochemical failure following radical prostatectomy and Androgen Deprivation Therapy (ADT) for prostate cancer

Sung-Gu Kang, Cheol Yong Yoon, Duck Ki Yoon

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Purpose: We explored the prognostic significance of obesity for the surgical and hormonal treatment of prostate cancer in correlation with the other prognostic factors such as Gleason's sum, the clinicopathologic stage, and the pre- and post treatment prostate specific antigen (PSA) changes. Materials and methods: A retrospective review was performed on 132 consecutive patients who had received androgen deprivation therapy (ADT) (108 patients) or radical prostatectomy (24 patients) under the diagnosis of prostate cancer via transrectal prostatic biopsy from July 1993 to May 2003 in our hospital. Obesity was evaluated in terms of the body mass index (BMI), and the patients were categorized into four groups according to the National Institute of Health (NIH) classification. The relationship between the BMI and the other prognostic factors were statistically analyzed by One-way ANOVA test and the Spearman correlation coefficient. Results: There were no significant associations between the BMI and any of the measured clinical and pathological parameters except for the time to hormone failure and biochemical recurrence. In the ADI group, the mean time to hormone failure was significantly longer in case of the low BMI group compared to the normal and overweight groups (p < 0.006). Sperman's correlation analysis showed a significant inverse correlation between the BMI and the PSA free survival after radical prostatectomy. Conclusions: These findings showed that the BMI is closely related to the failure to hormone treatment after ADI and the BMI was also related to the biological failures after radical prostatectomy.

Original languageEnglish
Pages (from-to)1262-1267
Number of pages6
JournalKorean Journal of Urology
Volume46
Issue number12
Publication statusPublished - 2005 Dec 1

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Prostatectomy
Androgens
Prostatic Neoplasms
Body Mass Index
Obesity
Hormones
Prostate-Specific Antigen
Therapeutics
National Institutes of Health (U.S.)
Analysis of Variance
Biopsy
Recurrence
Survival

Keywords

  • Body mass index
  • Obesity
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Obesity is an independent predictor of biochemical failure following radical prostatectomy and Androgen Deprivation Therapy (ADT) for prostate cancer. / Kang, Sung-Gu; Yoon, Cheol Yong; Yoon, Duck Ki.

In: Korean Journal of Urology, Vol. 46, No. 12, 01.12.2005, p. 1262-1267.

Research output: Contribution to journalReview article

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