TY - JOUR
T1 - Obesity phenotype and incident hypertension
T2 - A prospective community-based cohort study
AU - Lee, Seung Ku
AU - Kim, Seong Hwan
AU - Cho, Goo Yeong
AU - Baik, Inkyung
AU - Lim, Hong Euy
AU - Park, Chang Gyu
AU - Lee, Jung Bok
AU - Kim, Yong Hyun
AU - Lim, Sang Yup
AU - Kim, Hyun
AU - Shin, Chol
PY - 2013/1
Y1 - 2013/1
N2 - Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.
AB - Objective: The relationship betweens the healthy obese phenotype and the risk of cardiovascular events remains unclear. We prospectively investigated the association between the obesity phenotype and the incidence of hypertension. Methods: We studied 2352 participants, aged 40-69 years at baseline, with normal blood pressure (BP) from the Ansan cohort and the Ansung cohort of the Korean Genome Epidemiology Study. Participants were divided into six groups based on BMI and the metabolic syndrome (MetS) components: healthy (none of the five MetS components) normal weight (BMI <23 kg/m), unhealthy (one or more MetS component) normal weight, healthy overweight (BMI 23-24.9 kg/m), unhealthy overweight, healthy obesity (BMI 25 kg/m), and unhealthy obesity. The incidence of hypertension was identified by biennial health examinations during the 8-year follow-up. Results: After adjusting for age, sex, cohort, physical activity, smoking, alcohol consumption, and family history of hypertension and cardiovascular diseases, an increased risk for hypertension in combined cohort was observed in the healthy obesity [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.34-3.60], unhealthy overweight (HR: 1.47, 95% CI: 1.00-2.14), and unhealthy obesity (HR: 2.45, 95% CI: 1.79-3.37), compared with the healthy normal weight group. In each cohort, the healthy obesity was still associated with a higher incidence of hypertension (HR 2.20, 95% CI 1.11-4.36 for the Ansan cohort and HR 2.21, 95% CI 1.01-4.83 for the Ansung cohort). Conclusion: These findings provide evidence that the metabolically healthy obese phenotype may not be a benign condition.
KW - epidemiology
KW - hypertension
KW - metabolic syndrome
KW - obesity
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U2 - 10.1097/HJH.0b013e32835a3637
DO - 10.1097/HJH.0b013e32835a3637
M3 - Article
C2 - 23079679
AN - SCOPUS:84871712814
VL - 31
SP - 145
EP - 151
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 1
ER -