Obstructive Sleep Apnea in Patients with Persistent Atrial Fibrillation Is Independent Predictor for Failure of Biatrial Ablation

Dae In Lee, Jun Hyuk Kang, Young Hoon Kim

Research output: Contribution to journalArticle

Abstract

Background: Recent investigations demonstrated that obstructive sleep apnea (OSA) is an important precipitating factor of atrial fibrillation (AF).This study attempts to determine whether OSA can affect success rate of biatrial ablation in patients with persistent AF. Method: Fifty-six patients with longstanding persistent atrial fibrillation (LPAF) (Mean age 57±9.9) had undergone radiofrequency Catheter ablation (RFCA) including pulmonary vein isolation and 3-D complex fractionated atrial electrogram (CFAE) guided ablation at both atria.OSA was assessed by the Berlin Questionnaire (BQ). The primary endpoints during RF ablation were defined as complete elimination of the areas with CFAEs and conversion of AF to sinus rhythm. Result: Compared to patients with LPAF termination by biatrial ablation, patients who did not terminate AF (n=28, 50%) had a higher pulmonary pressure [33.1 ±6.4 mmHg vs. 29.0±3.5 mmHg, p=0.012] and greater number of the patients for high risk of OSA (n=17, 73.3%, vs. n=11, 41.5%,p = 0.032]. Univariate analysis revealed that age (OR 0.94, p= 0.038), pulmonary arterial pressure (OR 1.19, p= 0.023) and high risk for OSA (OR 3.38,p= 0.04) were related with failure of biatrial ablation. On multivariate analysis, age (OR 0.842, CI: 0.74 -0.96, p= 0.01) and high risk for OSA (OR 11.9, CI: 1.1-129.2, p= 0.04) were independent predictors for RFCA failure. Conclusion: High risk for OSA predicts RFCA failure after extensive biatrial ablation in patients with LPAF.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Obstructive Sleep Apnea
Atrial Fibrillation
Catheter Ablation
Cardiac Electrophysiologic Techniques
Precipitating Factors
Lung
Pulmonary Veins
Berlin
Arterial Pressure
Multivariate Analysis
Pressure

Keywords

  • biatrial ablation
  • obstructive sleep apnea
  • persistent atrial fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Obstructive Sleep Apnea in Patients with Persistent Atrial Fibrillation Is Independent Predictor for Failure of Biatrial Ablation. / Lee, Dae In; Kang, Jun Hyuk; Kim, Young Hoon.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

@article{4bec059afe2b44cd8269d0db88a8c486,
title = "Obstructive Sleep Apnea in Patients with Persistent Atrial Fibrillation Is Independent Predictor for Failure of Biatrial Ablation",
abstract = "Background: Recent investigations demonstrated that obstructive sleep apnea (OSA) is an important precipitating factor of atrial fibrillation (AF).This study attempts to determine whether OSA can affect success rate of biatrial ablation in patients with persistent AF. Method: Fifty-six patients with longstanding persistent atrial fibrillation (LPAF) (Mean age 57±9.9) had undergone radiofrequency Catheter ablation (RFCA) including pulmonary vein isolation and 3-D complex fractionated atrial electrogram (CFAE) guided ablation at both atria.OSA was assessed by the Berlin Questionnaire (BQ). The primary endpoints during RF ablation were defined as complete elimination of the areas with CFAEs and conversion of AF to sinus rhythm. Result: Compared to patients with LPAF termination by biatrial ablation, patients who did not terminate AF (n=28, 50{\%}) had a higher pulmonary pressure [33.1 ±6.4 mmHg vs. 29.0±3.5 mmHg, p=0.012] and greater number of the patients for high risk of OSA (n=17, 73.3{\%}, vs. n=11, 41.5{\%},p = 0.032]. Univariate analysis revealed that age (OR 0.94, p= 0.038), pulmonary arterial pressure (OR 1.19, p= 0.023) and high risk for OSA (OR 3.38,p= 0.04) were related with failure of biatrial ablation. On multivariate analysis, age (OR 0.842, CI: 0.74 -0.96, p= 0.01) and high risk for OSA (OR 11.9, CI: 1.1-129.2, p= 0.04) were independent predictors for RFCA failure. Conclusion: High risk for OSA predicts RFCA failure after extensive biatrial ablation in patients with LPAF.",
keywords = "biatrial ablation, obstructive sleep apnea, persistent atrial fibrillation",
author = "Lee, {Dae In} and Kang, {Jun Hyuk} and Kim, {Young Hoon}",
year = "2011",
month = "1",
day = "1",
doi = "10.4020/jhrs.27.OP21_6",
language = "English",
volume = "27",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Obstructive Sleep Apnea in Patients with Persistent Atrial Fibrillation Is Independent Predictor for Failure of Biatrial Ablation

AU - Lee, Dae In

AU - Kang, Jun Hyuk

AU - Kim, Young Hoon

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Recent investigations demonstrated that obstructive sleep apnea (OSA) is an important precipitating factor of atrial fibrillation (AF).This study attempts to determine whether OSA can affect success rate of biatrial ablation in patients with persistent AF. Method: Fifty-six patients with longstanding persistent atrial fibrillation (LPAF) (Mean age 57±9.9) had undergone radiofrequency Catheter ablation (RFCA) including pulmonary vein isolation and 3-D complex fractionated atrial electrogram (CFAE) guided ablation at both atria.OSA was assessed by the Berlin Questionnaire (BQ). The primary endpoints during RF ablation were defined as complete elimination of the areas with CFAEs and conversion of AF to sinus rhythm. Result: Compared to patients with LPAF termination by biatrial ablation, patients who did not terminate AF (n=28, 50%) had a higher pulmonary pressure [33.1 ±6.4 mmHg vs. 29.0±3.5 mmHg, p=0.012] and greater number of the patients for high risk of OSA (n=17, 73.3%, vs. n=11, 41.5%,p = 0.032]. Univariate analysis revealed that age (OR 0.94, p= 0.038), pulmonary arterial pressure (OR 1.19, p= 0.023) and high risk for OSA (OR 3.38,p= 0.04) were related with failure of biatrial ablation. On multivariate analysis, age (OR 0.842, CI: 0.74 -0.96, p= 0.01) and high risk for OSA (OR 11.9, CI: 1.1-129.2, p= 0.04) were independent predictors for RFCA failure. Conclusion: High risk for OSA predicts RFCA failure after extensive biatrial ablation in patients with LPAF.

AB - Background: Recent investigations demonstrated that obstructive sleep apnea (OSA) is an important precipitating factor of atrial fibrillation (AF).This study attempts to determine whether OSA can affect success rate of biatrial ablation in patients with persistent AF. Method: Fifty-six patients with longstanding persistent atrial fibrillation (LPAF) (Mean age 57±9.9) had undergone radiofrequency Catheter ablation (RFCA) including pulmonary vein isolation and 3-D complex fractionated atrial electrogram (CFAE) guided ablation at both atria.OSA was assessed by the Berlin Questionnaire (BQ). The primary endpoints during RF ablation were defined as complete elimination of the areas with CFAEs and conversion of AF to sinus rhythm. Result: Compared to patients with LPAF termination by biatrial ablation, patients who did not terminate AF (n=28, 50%) had a higher pulmonary pressure [33.1 ±6.4 mmHg vs. 29.0±3.5 mmHg, p=0.012] and greater number of the patients for high risk of OSA (n=17, 73.3%, vs. n=11, 41.5%,p = 0.032]. Univariate analysis revealed that age (OR 0.94, p= 0.038), pulmonary arterial pressure (OR 1.19, p= 0.023) and high risk for OSA (OR 3.38,p= 0.04) were related with failure of biatrial ablation. On multivariate analysis, age (OR 0.842, CI: 0.74 -0.96, p= 0.01) and high risk for OSA (OR 11.9, CI: 1.1-129.2, p= 0.04) were independent predictors for RFCA failure. Conclusion: High risk for OSA predicts RFCA failure after extensive biatrial ablation in patients with LPAF.

KW - biatrial ablation

KW - obstructive sleep apnea

KW - persistent atrial fibrillation

UR - http://www.scopus.com/inward/record.url?scp=85009647960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009647960&partnerID=8YFLogxK

U2 - 10.4020/jhrs.27.OP21_6

DO - 10.4020/jhrs.27.OP21_6

M3 - Article

VL - 27

JO - Journal of Arrhythmia

JF - Journal of Arrhythmia

SN - 1880-4276

IS - 4

ER -