Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA

S. Gilman, R. D. Chervin, R. A. Koeppe, F. B. Consens, R. Little, Hyonggin An, L. Junck, M. Heumann

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Objective: To explore the neurochemical basis of obstructive sleep apnea (OSA) in multiple-system atrophy (MSA). Methods: In 13 patients with probable MSA, nocturnal, laboratory-based polysomnography was used to rate the severity of OSA using the apnea-hypopnea index during sleep. SPECT with (-)-5-[123I]iodobenzovesamicol ([123I]IBVM) was utilized to measure the density of thalamic cholinergic terminals, which project from the brainstem pedunculopontine and laterodorsal tegmental nuclei. PET with (+)-[11C]dihydrotetrabenazine ([11C]DTBZ) was also used to measure the density of striatal monoaminergic terminals, which project from the brainstem. Findings in the patient group were compared with data from 12 normal control subjects scanned utilizing [123I]IBVM and 15 normal control subjects utilizing [11C]DTBZ. Results: Age and gender distributions were similar in patient and control groups. The MSA subjects showed decreased [123I]IBVM binding in the thalamus (p < 0.001) and decreased mean [11C]DTBZ binding in the striatum (p < 0.0001) in comparison with the control subjects. In the MSA group, thalamic [123I]IBVM binding was inversely correlated with the severity of OSA (p = 0.011). Striatal [11C]DTBZ binding was not correlated with the severity of OSA (p = 0.19). Conclusion: Decreased pontine cholinergic projections may contribute to OSA in MSA.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalNeurology
Volume61
Issue number1
DOIs
Publication statusPublished - 2003 Jul 8
Externally publishedYes

Fingerprint

Multiple System Atrophy
Obstructive Sleep Apnea
Cholinergic Agents
Corpus Striatum
Brain Stem
Pedunculopontine Tegmental Nucleus
Polysomnography
Age Distribution
Apnea
Single-Photon Emission-Computed Tomography
Thalamus
Sleep
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Gilman, S., Chervin, R. D., Koeppe, R. A., Consens, F. B., Little, R., An, H., ... Heumann, M. (2003). Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. Neurology, 61(1), 35-39. https://doi.org/10.1212/01.WNL.0000073624.13436.32

Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. / Gilman, S.; Chervin, R. D.; Koeppe, R. A.; Consens, F. B.; Little, R.; An, Hyonggin; Junck, L.; Heumann, M.

In: Neurology, Vol. 61, No. 1, 08.07.2003, p. 35-39.

Research output: Contribution to journalArticle

Gilman, S, Chervin, RD, Koeppe, RA, Consens, FB, Little, R, An, H, Junck, L & Heumann, M 2003, 'Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA', Neurology, vol. 61, no. 1, pp. 35-39. https://doi.org/10.1212/01.WNL.0000073624.13436.32
Gilman, S. ; Chervin, R. D. ; Koeppe, R. A. ; Consens, F. B. ; Little, R. ; An, Hyonggin ; Junck, L. ; Heumann, M. / Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. In: Neurology. 2003 ; Vol. 61, No. 1. pp. 35-39.
@article{422d22071db8418ea8212099715c451c,
title = "Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA",
abstract = "Objective: To explore the neurochemical basis of obstructive sleep apnea (OSA) in multiple-system atrophy (MSA). Methods: In 13 patients with probable MSA, nocturnal, laboratory-based polysomnography was used to rate the severity of OSA using the apnea-hypopnea index during sleep. SPECT with (-)-5-[123I]iodobenzovesamicol ([123I]IBVM) was utilized to measure the density of thalamic cholinergic terminals, which project from the brainstem pedunculopontine and laterodorsal tegmental nuclei. PET with (+)-[11C]dihydrotetrabenazine ([11C]DTBZ) was also used to measure the density of striatal monoaminergic terminals, which project from the brainstem. Findings in the patient group were compared with data from 12 normal control subjects scanned utilizing [123I]IBVM and 15 normal control subjects utilizing [11C]DTBZ. Results: Age and gender distributions were similar in patient and control groups. The MSA subjects showed decreased [123I]IBVM binding in the thalamus (p < 0.001) and decreased mean [11C]DTBZ binding in the striatum (p < 0.0001) in comparison with the control subjects. In the MSA group, thalamic [123I]IBVM binding was inversely correlated with the severity of OSA (p = 0.011). Striatal [11C]DTBZ binding was not correlated with the severity of OSA (p = 0.19). Conclusion: Decreased pontine cholinergic projections may contribute to OSA in MSA.",
author = "S. Gilman and Chervin, {R. D.} and Koeppe, {R. A.} and Consens, {F. B.} and R. Little and Hyonggin An and L. Junck and M. Heumann",
year = "2003",
month = "7",
day = "8",
doi = "10.1212/01.WNL.0000073624.13436.32",
language = "English",
volume = "61",
pages = "35--39",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA

AU - Gilman, S.

AU - Chervin, R. D.

AU - Koeppe, R. A.

AU - Consens, F. B.

AU - Little, R.

AU - An, Hyonggin

AU - Junck, L.

AU - Heumann, M.

PY - 2003/7/8

Y1 - 2003/7/8

N2 - Objective: To explore the neurochemical basis of obstructive sleep apnea (OSA) in multiple-system atrophy (MSA). Methods: In 13 patients with probable MSA, nocturnal, laboratory-based polysomnography was used to rate the severity of OSA using the apnea-hypopnea index during sleep. SPECT with (-)-5-[123I]iodobenzovesamicol ([123I]IBVM) was utilized to measure the density of thalamic cholinergic terminals, which project from the brainstem pedunculopontine and laterodorsal tegmental nuclei. PET with (+)-[11C]dihydrotetrabenazine ([11C]DTBZ) was also used to measure the density of striatal monoaminergic terminals, which project from the brainstem. Findings in the patient group were compared with data from 12 normal control subjects scanned utilizing [123I]IBVM and 15 normal control subjects utilizing [11C]DTBZ. Results: Age and gender distributions were similar in patient and control groups. The MSA subjects showed decreased [123I]IBVM binding in the thalamus (p < 0.001) and decreased mean [11C]DTBZ binding in the striatum (p < 0.0001) in comparison with the control subjects. In the MSA group, thalamic [123I]IBVM binding was inversely correlated with the severity of OSA (p = 0.011). Striatal [11C]DTBZ binding was not correlated with the severity of OSA (p = 0.19). Conclusion: Decreased pontine cholinergic projections may contribute to OSA in MSA.

AB - Objective: To explore the neurochemical basis of obstructive sleep apnea (OSA) in multiple-system atrophy (MSA). Methods: In 13 patients with probable MSA, nocturnal, laboratory-based polysomnography was used to rate the severity of OSA using the apnea-hypopnea index during sleep. SPECT with (-)-5-[123I]iodobenzovesamicol ([123I]IBVM) was utilized to measure the density of thalamic cholinergic terminals, which project from the brainstem pedunculopontine and laterodorsal tegmental nuclei. PET with (+)-[11C]dihydrotetrabenazine ([11C]DTBZ) was also used to measure the density of striatal monoaminergic terminals, which project from the brainstem. Findings in the patient group were compared with data from 12 normal control subjects scanned utilizing [123I]IBVM and 15 normal control subjects utilizing [11C]DTBZ. Results: Age and gender distributions were similar in patient and control groups. The MSA subjects showed decreased [123I]IBVM binding in the thalamus (p < 0.001) and decreased mean [11C]DTBZ binding in the striatum (p < 0.0001) in comparison with the control subjects. In the MSA group, thalamic [123I]IBVM binding was inversely correlated with the severity of OSA (p = 0.011). Striatal [11C]DTBZ binding was not correlated with the severity of OSA (p = 0.19). Conclusion: Decreased pontine cholinergic projections may contribute to OSA in MSA.

UR - http://www.scopus.com/inward/record.url?scp=0038691965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038691965&partnerID=8YFLogxK

U2 - 10.1212/01.WNL.0000073624.13436.32

DO - 10.1212/01.WNL.0000073624.13436.32

M3 - Article

VL - 61

SP - 35

EP - 39

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -