Abstract
The purpose of this study was to review the existing studies on lymphohematopoietic (LHP) cancer in Korea, estimate the prevalence of workers exposed to carcinogens, and determine the population attributable fraction (PAF) of leukemia. Two case series and 4 case reports were reviewed. Using official statistics, the prevalence of benzene exposure and ionizing radiation exposure was estimated. Based on the prevalence of exposure and the relative risk, The PAF of leukemia was calculated. Between 1996 and 2005, 51 cases of LHP cancer were reported from the compensation system. Greater than 50% of occupational LHP cancer was leukemia, and the most important cause was benzene. In a cohort study, the standardized incidence ratio was 2.71 (95% CI, 0.56-7.91). The prevalence of exposure was 2.5% and 2.2% in 1995 and 2000, respectively. Using the 1995 prevalence, 3.6-4.8% and 0.1% of cases with leukemia were attributable to benzene and ionizing radiation exposure, respectively, which resulted in 39.7-51.4 cases per year. Benzene is the most important cause of occupational leukemia in Korea. Considering the estimated PAF in this study, the annual number of occupational LHP cancer (51 cases during 10-yr period), might be underreported within the compensation system.
| Original language | English |
|---|---|
| Journal | Journal of Korean Medical Science |
| Volume | 25 |
| Issue number | SUPPL.1 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
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Keywords
- Benzene
- Lymphohematopoietic
- Occupational Cancer
- Population Attributable Fraction
ASJC Scopus subject areas
- Medicine(all)
Cite this
Occupational lymphohematopoietic cancer in Korea. / Kim, Eun A.; Lee, Won Jin; Son, Mia; Kang, Seong Kyu.
In: Journal of Korean Medical Science, Vol. 25, No. SUPPL.1, 01.01.2010.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Occupational lymphohematopoietic cancer in Korea
AU - Kim, Eun A.
AU - Lee, Won Jin
AU - Son, Mia
AU - Kang, Seong Kyu
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The purpose of this study was to review the existing studies on lymphohematopoietic (LHP) cancer in Korea, estimate the prevalence of workers exposed to carcinogens, and determine the population attributable fraction (PAF) of leukemia. Two case series and 4 case reports were reviewed. Using official statistics, the prevalence of benzene exposure and ionizing radiation exposure was estimated. Based on the prevalence of exposure and the relative risk, The PAF of leukemia was calculated. Between 1996 and 2005, 51 cases of LHP cancer were reported from the compensation system. Greater than 50% of occupational LHP cancer was leukemia, and the most important cause was benzene. In a cohort study, the standardized incidence ratio was 2.71 (95% CI, 0.56-7.91). The prevalence of exposure was 2.5% and 2.2% in 1995 and 2000, respectively. Using the 1995 prevalence, 3.6-4.8% and 0.1% of cases with leukemia were attributable to benzene and ionizing radiation exposure, respectively, which resulted in 39.7-51.4 cases per year. Benzene is the most important cause of occupational leukemia in Korea. Considering the estimated PAF in this study, the annual number of occupational LHP cancer (51 cases during 10-yr period), might be underreported within the compensation system.
AB - The purpose of this study was to review the existing studies on lymphohematopoietic (LHP) cancer in Korea, estimate the prevalence of workers exposed to carcinogens, and determine the population attributable fraction (PAF) of leukemia. Two case series and 4 case reports were reviewed. Using official statistics, the prevalence of benzene exposure and ionizing radiation exposure was estimated. Based on the prevalence of exposure and the relative risk, The PAF of leukemia was calculated. Between 1996 and 2005, 51 cases of LHP cancer were reported from the compensation system. Greater than 50% of occupational LHP cancer was leukemia, and the most important cause was benzene. In a cohort study, the standardized incidence ratio was 2.71 (95% CI, 0.56-7.91). The prevalence of exposure was 2.5% and 2.2% in 1995 and 2000, respectively. Using the 1995 prevalence, 3.6-4.8% and 0.1% of cases with leukemia were attributable to benzene and ionizing radiation exposure, respectively, which resulted in 39.7-51.4 cases per year. Benzene is the most important cause of occupational leukemia in Korea. Considering the estimated PAF in this study, the annual number of occupational LHP cancer (51 cases during 10-yr period), might be underreported within the compensation system.
KW - Benzene
KW - Lymphohematopoietic
KW - Occupational Cancer
KW - Population Attributable Fraction
UR - http://www.scopus.com/inward/record.url?scp=79961046327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961046327&partnerID=8YFLogxK
U2 - 10.3346/jkms.2010.25.S.S99
DO - 10.3346/jkms.2010.25.S.S99
M3 - Review article
C2 - 21258598
AN - SCOPUS:79961046327
VL - 25
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - SUPPL.1
ER -