Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea

Gyuyeon Choi; Sungjoo Kim; Sunmi Kim; Sungkyoon Kim; Youngeun Choi; Hai Joong Kim; Jeong Jae Lee; Su Young Kim; Sunggyu Lee; Hyo Bang Moon; Sooran Choi; Kyungho Choi; Jeongim Park

doi:10.1016/j.scitotenv.2014.02.071

Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea

Gyuyeon Choi, Sungjoo Kim, Sunmi Kim, Sungkyoon Kim, Youngeun Choi, Hai Joong Kim, Jeong Jae Lee, Su Young Kim, Sunggyu Lee, Hyo Bang Moon, Sooran Choi, Kyungho Choi, Jeongim Park

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of pregnant women and their matching newborn infants. For this purpose, a total of 198 maternal blood samples and 118 matching umbilical cord blood samples were collected from four regions of South Korea in 2011, and were determined for 19 PBDE congeners. Various demographic, dietary, and behavioral characteristics were asked in a questionnaire survey. Average concentration of total PBDEs in maternal blood serum was 3.34 ± 8.42. ng/g lipid weight (lw) at delivery and 3.14 ± 7.46. ng/g lw at 6. months of pregnancy, respectively. In cord blood serum, an average of 9.37 ± 12.60. ng/g lw was detected. Among the measured PBDE congeners, BDE-47, BDE-99 and BDE-153 were most dominant in both maternal and cord blood sera. Relatively higher levels of BDE-99 were detected in cord blood serum. Strong positive correlations were detected between maternal and cord blood serum samples, indicating the importance of maternal transfer. Health consequences of transplacental exposure to PBDEs among fetuses and newborn infants warrant further investigation.

Original language	English
Pages (from-to)	219-226
Number of pages	8
Journal	Science of the Total Environment
Volume	491-492
DOIs	https://doi.org/10.1016/j.scitotenv.2014.02.071
Publication status	Published - 2014 Sept 1
Externally published	Yes

Keywords

BDE-153
BDE-47
BDE-99
Infant
Pregnant women
Transplacental

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scitotenv.2014.02.071

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@article{16c830f5aad444aa830f9004c37f2976,

title = "Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea",

abstract = "Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of pregnant women and their matching newborn infants. For this purpose, a total of 198 maternal blood samples and 118 matching umbilical cord blood samples were collected from four regions of South Korea in 2011, and were determined for 19 PBDE congeners. Various demographic, dietary, and behavioral characteristics were asked in a questionnaire survey. Average concentration of total PBDEs in maternal blood serum was 3.34 ± 8.42. ng/g lipid weight (lw) at delivery and 3.14 ± 7.46. ng/g lw at 6. months of pregnancy, respectively. In cord blood serum, an average of 9.37 ± 12.60. ng/g lw was detected. Among the measured PBDE congeners, BDE-47, BDE-99 and BDE-153 were most dominant in both maternal and cord blood sera. Relatively higher levels of BDE-99 were detected in cord blood serum. Strong positive correlations were detected between maternal and cord blood serum samples, indicating the importance of maternal transfer. Health consequences of transplacental exposure to PBDEs among fetuses and newborn infants warrant further investigation.",

keywords = "BDE-153, BDE-47, BDE-99, Infant, Pregnant women, Transplacental",

author = "Gyuyeon Choi and Sungjoo Kim and Sunmi Kim and Sungkyoon Kim and Youngeun Choi and Kim, {Hai Joong} and Lee, {Jeong Jae} and Kim, {Su Young} and Sunggyu Lee and Moon, {Hyo Bang} and Sooran Choi and Kyungho Choi and Jeongim Park",

note = "Funding Information: We would like to express our gratitude to all participating mothers and newborn infants. This study was supported by Korea Food and Drug Administration ( 11162KFDA722 ).",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.scitotenv.2014.02.071",

language = "English",

volume = "491-492",

pages = "219--226",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier",

}

TY - JOUR

T1 - Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea

AU - Choi, Gyuyeon

AU - Kim, Sungjoo

AU - Kim, Sunmi

AU - Kim, Sungkyoon

AU - Choi, Youngeun

AU - Kim, Hai Joong

AU - Lee, Jeong Jae

AU - Kim, Su Young

AU - Lee, Sunggyu

AU - Moon, Hyo Bang

AU - Choi, Sooran

AU - Choi, Kyungho

AU - Park, Jeongim

N1 - Funding Information: We would like to express our gratitude to all participating mothers and newborn infants. This study was supported by Korea Food and Drug Administration ( 11162KFDA722 ).

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of pregnant women and their matching newborn infants. For this purpose, a total of 198 maternal blood samples and 118 matching umbilical cord blood samples were collected from four regions of South Korea in 2011, and were determined for 19 PBDE congeners. Various demographic, dietary, and behavioral characteristics were asked in a questionnaire survey. Average concentration of total PBDEs in maternal blood serum was 3.34 ± 8.42. ng/g lipid weight (lw) at delivery and 3.14 ± 7.46. ng/g lw at 6. months of pregnancy, respectively. In cord blood serum, an average of 9.37 ± 12.60. ng/g lw was detected. Among the measured PBDE congeners, BDE-47, BDE-99 and BDE-153 were most dominant in both maternal and cord blood sera. Relatively higher levels of BDE-99 were detected in cord blood serum. Strong positive correlations were detected between maternal and cord blood serum samples, indicating the importance of maternal transfer. Health consequences of transplacental exposure to PBDEs among fetuses and newborn infants warrant further investigation.

AB - Polybrominated diphenyl ethers (PBDEs) are of growing public health concern because of their potential toxicities which range from endocrine disruption to neurodevelopment. However, information on their exposure among sensitive human populations is limited. The objectives of this study were to determine the levels of major PBDEs in blood sera of pregnant women and their matching newborn infants. For this purpose, a total of 198 maternal blood samples and 118 matching umbilical cord blood samples were collected from four regions of South Korea in 2011, and were determined for 19 PBDE congeners. Various demographic, dietary, and behavioral characteristics were asked in a questionnaire survey. Average concentration of total PBDEs in maternal blood serum was 3.34 ± 8.42. ng/g lipid weight (lw) at delivery and 3.14 ± 7.46. ng/g lw at 6. months of pregnancy, respectively. In cord blood serum, an average of 9.37 ± 12.60. ng/g lw was detected. Among the measured PBDE congeners, BDE-47, BDE-99 and BDE-153 were most dominant in both maternal and cord blood sera. Relatively higher levels of BDE-99 were detected in cord blood serum. Strong positive correlations were detected between maternal and cord blood serum samples, indicating the importance of maternal transfer. Health consequences of transplacental exposure to PBDEs among fetuses and newborn infants warrant further investigation.

KW - BDE-153

KW - BDE-47

KW - BDE-99

KW - Infant

KW - Pregnant women

KW - Transplacental

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U2 - 10.1016/j.scitotenv.2014.02.071

DO - 10.1016/j.scitotenv.2014.02.071

M3 - Article

C2 - 24636800

AN - SCOPUS:84903541468

SN - 0048-9697

VL - 491-492

SP - 219

EP - 226

JO - Science of the Total Environment

JF - Science of the Total Environment

ER -

Occurrences of major polybrominated diphenyl ethers (PBDEs) in maternal and fetal cord blood sera in Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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