Oil-free generation of small polymeric particles using a coaxial microfluidic channel

SuJung Shin, Joung Sook Hong, Kwang Ho Lee, Sang Hoon Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, a microfluidic method to generate small polymeric particles (10 μm in diameter) via the control of interfacial tension without using oil and in situ photopolymerization immediately after drop generation was introduced. For the reduction in size, the selection of proper sample and sheath liquid to minimize the interfacial tension is extremely important, and 4-HBA (4-hydroxybutyl acrylate) andPVA(poly(vinyl acrylate)) were employed as core and sheath fluid pair because of much smaller surface tension than the case using oil. In addition, PVA is easily washable by aqueous solution, which is a strong advantage when the particle is applied in biomedical fields. The viscosity effect of sheath flow was also examined for further size reduction. The loading and release properties of proteins were evaluated using fluorescently labeled bovine serum albumin for the potential application as drug carrier. The protein was uniformly loaded into particles, and the protein release rate was dependent on the particle size. For utility in the biomedical area, the cyto-compatibility test of 4-HBA was performed by culturing glioma cells on the 4-HBA sheet, and the cells were alive well after 4 days culture. Conclusively, this oil-free particle generation methods facilitates the generation of uniform and small particles in a simple way without an oil-washing process.

Original languageEnglish
Pages (from-to)12361-12366
Number of pages6
JournalLangmuir
Volume25
Issue number20
DOIs
Publication statusPublished - 2009 Oct 20

Fingerprint

Microfluidics
Surface Tension
Oils
oils
acrylates
Surface tension
Proteins
sheaths
interfacial tension
proteins
Drug Carriers
Photopolymerization
Bovine Serum Albumin
cell culturing
Particle Size
Washing
Viscosity
Glioma
Particle size
washing

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy
  • Medicine(all)

Cite this

Oil-free generation of small polymeric particles using a coaxial microfluidic channel. / Shin, SuJung; Hong, Joung Sook; Lee, Kwang Ho; Lee, Sang Hoon.

In: Langmuir, Vol. 25, No. 20, 20.10.2009, p. 12361-12366.

Research output: Contribution to journalArticle

Shin, SuJung ; Hong, Joung Sook ; Lee, Kwang Ho ; Lee, Sang Hoon. / Oil-free generation of small polymeric particles using a coaxial microfluidic channel. In: Langmuir. 2009 ; Vol. 25, No. 20. pp. 12361-12366.
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