Olfactory neuroblastoma following treatment for pituitary adenoma

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Olfactory neuroblastoma is extremely rare as a second neoplasm. We report an unusual case of olfactory neuroblastoma in a 59-year-old woman who had undergone two operations and received 54 Gy of irradiation for pituitary adenoma 20 years ago. At the time of admission, the patient presented with nasal obstruction and frequent epistaxis. Imaging studies showed a large mass in the nasal cavities and ethmoid sinus, extending to the intracranial area, with no evidence of any recurrence of the previous pituitary adenoma. The tumor was completely excised via a trans-cranial and trans-nasal approach. A diagnosis of olfactory neuroblastoma was established, and the patient was given postoperative chemotherapy. Although relatively uncommon, second neoplasms are an important consideration in the differential diagnosis of patients with new or recurring symptoms after treatment for pituitary adenoma. Furthermore, it is likely that radiation played a critical role in the development of olfactory neuroblastoma in our patient.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalJournal of Neuro-Oncology
Volume90
Issue number2
DOIs
Publication statusPublished - 2008 Aug 6

Fingerprint

Olfactory Esthesioneuroblastoma
Pituitary Neoplasms
Second Primary Neoplasms
Ethmoid Sinus
Nasal Obstruction
Epistaxis
Paranasal Sinuses
Nasal Cavity
Patient Admission
Therapeutics
Nose
Differential Diagnosis
Radiation
Recurrence
Drug Therapy
Neoplasms

Keywords

  • Olfactory neuroblastoma
  • Pituitary adenoma
  • Radiation-induced neoplasm
  • Second neoplasm

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Olfactory neuroblastoma following treatment for pituitary adenoma. / Park, Kyung-Jae; Kang, Shin-Hyuk; Lee, Hoon Gab; Chung, Yong Gu.

In: Journal of Neuro-Oncology, Vol. 90, No. 2, 06.08.2008, p. 237-241.

Research output: Contribution to journalArticle

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