Oligonucleotides as transcription factor decoys

Yoon S. Cho-Chung, Yun Gyu Park, Youl Nam Lee

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Cellular and molecular research has been focused to develop a means to regulate gene expression in an effort to treat and cure a variety of diseases and abnormal physiological conditions. A successful oligonucleotide-based approach has been the use of synthetic oligonucleotides containing an enhancer element that can penetrate cells, bind sequence-specific DNA- binding proteins and interfere with transcription in vivo. This review describes such decoy oligonucleotides that exhibit high affinity for a target transcription factor and successfully interfere with transcription in vivo. Evidence presented here shows that the decoy oligonucleotide technology offers great promise as a tool for defining cellular regulatory processes and for treating cancer, viral diseases and other pathological conditions.

Original languageEnglish
Pages (from-to)386-392
Number of pages7
JournalCurrent Opinion in Molecular Therapeutics
Volume1
Issue number3
Publication statusPublished - 1999 Jun 1
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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