On-chip erythrocyte deformability test under optical pressure

Won Gu Lee, Hyunwoo Bang, Hoyoung Yun, Joonmo Lee, Junha Park, Jung Kyung Kim, Seok Chung, Keunchang Cho, Chanil Chung, Dong Chul Han, Jun Keun Chang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect to the detection of cancerous diseases. To demonstrate the performance and sensitivity of the combined method, we introduce the concept of transit velocity, a modified elongation index, and shape recovery time of individual erythrocytes in a strictly confined region (2 μm deep, 4 μm wide, and 100 μm long). Finally, we investigate a synergy or convergence effect due to the combination of these parameters for in situ detection of cancerous diseases under optical pressure.

Original languageEnglish
Pages (from-to)516-519
Number of pages4
JournalLab on a Chip
Volume7
Issue number4
DOIs
Publication statusPublished - 2007 Jan 1

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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  • Cite this

    Lee, W. G., Bang, H., Yun, H., Lee, J., Park, J., Kim, J. K., Chung, S., Cho, K., Chung, C., Han, D. C., & Chang, J. K. (2007). On-chip erythrocyte deformability test under optical pressure. Lab on a Chip, 7(4), 516-519. https://doi.org/10.1039/b614912j