On-Water Synthesis of 2-Substituted Quinolines from 2-Aminochalcones Using Benzylamine as the Nucleophilic Catalyst

So Young Lee, Cheol-Hong Cheon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

On-water synthesis of 2-substituted quinolines from 2-aminochalcone derivatives was developed using benzylamine as the nucleophilic catalyst. Various 2-aminochalcones could be applied to this protocol, and the desired 2-substituted quinoline products were isolated in excellent yields by simple filtration. Furthermore, we elucidated the role of benzylamine in this transformation and provided the detailed reaction mechanism. This protocol has several additional advantages, such as simple operation, broad substrate scope, good functional group tolerance, easy product isolation, recycling of the catalyst, and gram-scale synthesis.

Original languageEnglish
Pages (from-to)13036-13044
Number of pages9
JournalJournal of Organic Chemistry
Volume83
Issue number21
DOIs
Publication statusPublished - 2018 Nov 2

ASJC Scopus subject areas

  • Organic Chemistry

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