Oncologic outcomes in rectal cancer patients with a ≤1-cm distal resection margin

Dong Woo Kang, Han Deok Kwak, Nak Song Sung, In Soo Yang, Se-Jin Baek, Jung-Myun Kwak, Jin Kim, Seon Hahn Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Recently, common application of sphincter-saving resection in rectal cancer has led to acceptance of a 1-cm distal resection margin (DRM). The aim of this study was to evaluate oncologic outcomes of a DRM ≤1 cm in sphincter-saving resection for rectal cancer. The outcomes of a DRM ≤0.5 cm was also evaluated. Methods: We reviewed prospectively collected data from 415 patients who underwent sphincter-saving resection for mid and low rectal cancer between September 2006 and December 2012 at Korea University Anam Hospital. Patients were divided into two groups according to DRM measured in a formalin fixed specimen: ≤1 cm (n = 132) and >1 cm (n = 283). The DRM ≤1 cm group was divided into two subgroups: ≤0.5 cm (n = 45) and >0.5, ≤1 cm (n = 87). Results: Median follow-up periods were 47.2 months. The 5-year local recurrence rate was 8.8% in the DRM ≤1 cm group and 8.5% in the DRM >1 cm group (p = 0.630). The 5-year disease-free survival rate was 75.1 and 76.3% (p = 0.895), and the 5-year overall survival rate was 82.6 and 85.9% (p = 0.401), respectively. In subanalysis of the DRM ≤1 cm group, there was also no significant difference in the local recurrence and survival. Conclusions: There was no significant difference in local recurrence and survival based on DRM length. We found that DRM length less than 1 cm was not a prognostic factor for local recurrence or survival.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalInternational Journal of Colorectal Disease
Volume32
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

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Rectal Neoplasms
Recurrence
Survival
Survival Rate
Margins of Excision
Korea
Formaldehyde
Disease-Free Survival

Keywords

  • Distal resection margin
  • Oncologic outcomes
  • Rectal neoplasm
  • Sphincter-saving resection

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Oncologic outcomes in rectal cancer patients with a ≤1-cm distal resection margin. / Kang, Dong Woo; Kwak, Han Deok; Sung, Nak Song; Yang, In Soo; Baek, Se-Jin; Kwak, Jung-Myun; Kim, Jin; Kim, Seon Hahn.

In: International Journal of Colorectal Disease, Vol. 32, No. 3, 01.03.2017, p. 325-332.

Research output: Contribution to journalArticle

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abstract = "Purpose: Recently, common application of sphincter-saving resection in rectal cancer has led to acceptance of a 1-cm distal resection margin (DRM). The aim of this study was to evaluate oncologic outcomes of a DRM ≤1 cm in sphincter-saving resection for rectal cancer. The outcomes of a DRM ≤0.5 cm was also evaluated. Methods: We reviewed prospectively collected data from 415 patients who underwent sphincter-saving resection for mid and low rectal cancer between September 2006 and December 2012 at Korea University Anam Hospital. Patients were divided into two groups according to DRM measured in a formalin fixed specimen: ≤1 cm (n = 132) and >1 cm (n = 283). The DRM ≤1 cm group was divided into two subgroups: ≤0.5 cm (n = 45) and >0.5, ≤1 cm (n = 87). Results: Median follow-up periods were 47.2 months. The 5-year local recurrence rate was 8.8{\%} in the DRM ≤1 cm group and 8.5{\%} in the DRM >1 cm group (p = 0.630). The 5-year disease-free survival rate was 75.1 and 76.3{\%} (p = 0.895), and the 5-year overall survival rate was 82.6 and 85.9{\%} (p = 0.401), respectively. In subanalysis of the DRM ≤1 cm group, there was also no significant difference in the local recurrence and survival. Conclusions: There was no significant difference in local recurrence and survival based on DRM length. We found that DRM length less than 1 cm was not a prognostic factor for local recurrence or survival.",
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T1 - Oncologic outcomes in rectal cancer patients with a ≤1-cm distal resection margin

AU - Kang, Dong Woo

AU - Kwak, Han Deok

AU - Sung, Nak Song

AU - Yang, In Soo

AU - Baek, Se-Jin

AU - Kwak, Jung-Myun

AU - Kim, Jin

AU - Kim, Seon Hahn

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N2 - Purpose: Recently, common application of sphincter-saving resection in rectal cancer has led to acceptance of a 1-cm distal resection margin (DRM). The aim of this study was to evaluate oncologic outcomes of a DRM ≤1 cm in sphincter-saving resection for rectal cancer. The outcomes of a DRM ≤0.5 cm was also evaluated. Methods: We reviewed prospectively collected data from 415 patients who underwent sphincter-saving resection for mid and low rectal cancer between September 2006 and December 2012 at Korea University Anam Hospital. Patients were divided into two groups according to DRM measured in a formalin fixed specimen: ≤1 cm (n = 132) and >1 cm (n = 283). The DRM ≤1 cm group was divided into two subgroups: ≤0.5 cm (n = 45) and >0.5, ≤1 cm (n = 87). Results: Median follow-up periods were 47.2 months. The 5-year local recurrence rate was 8.8% in the DRM ≤1 cm group and 8.5% in the DRM >1 cm group (p = 0.630). The 5-year disease-free survival rate was 75.1 and 76.3% (p = 0.895), and the 5-year overall survival rate was 82.6 and 85.9% (p = 0.401), respectively. In subanalysis of the DRM ≤1 cm group, there was also no significant difference in the local recurrence and survival. Conclusions: There was no significant difference in local recurrence and survival based on DRM length. We found that DRM length less than 1 cm was not a prognostic factor for local recurrence or survival.

AB - Purpose: Recently, common application of sphincter-saving resection in rectal cancer has led to acceptance of a 1-cm distal resection margin (DRM). The aim of this study was to evaluate oncologic outcomes of a DRM ≤1 cm in sphincter-saving resection for rectal cancer. The outcomes of a DRM ≤0.5 cm was also evaluated. Methods: We reviewed prospectively collected data from 415 patients who underwent sphincter-saving resection for mid and low rectal cancer between September 2006 and December 2012 at Korea University Anam Hospital. Patients were divided into two groups according to DRM measured in a formalin fixed specimen: ≤1 cm (n = 132) and >1 cm (n = 283). The DRM ≤1 cm group was divided into two subgroups: ≤0.5 cm (n = 45) and >0.5, ≤1 cm (n = 87). Results: Median follow-up periods were 47.2 months. The 5-year local recurrence rate was 8.8% in the DRM ≤1 cm group and 8.5% in the DRM >1 cm group (p = 0.630). The 5-year disease-free survival rate was 75.1 and 76.3% (p = 0.895), and the 5-year overall survival rate was 82.6 and 85.9% (p = 0.401), respectively. In subanalysis of the DRM ≤1 cm group, there was also no significant difference in the local recurrence and survival. Conclusions: There was no significant difference in local recurrence and survival based on DRM length. We found that DRM length less than 1 cm was not a prognostic factor for local recurrence or survival.

KW - Distal resection margin

KW - Oncologic outcomes

KW - Rectal neoplasm

KW - Sphincter-saving resection

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