Oncostatin M, a muscle-secreted myokine, recovers high-glucose-induced impairment of Akt phosphorylation by Fos induction in hippocampal neuron cells

William Won Seok Hyung, Sung Gon Lee, Keun Tae Kim, Hyeon Soo Kim

Research output: Contribution to journalArticle

Abstract

Oncostatin M is a muscle-secreted myokine that has various effects on neuronal function, however, the underlying molecular mechanism has been poorly defined. In this study, we showed that Oncostatin M increased the phosphorylation of Akt and ERK, proteins crucial for neuron cell survival and proliferation. Furthermore, Oncostatin M increased the expression of c-Fos, a protein with significant involvement in neuronal cell proliferation and survival, through both Akt and ERK. Oncostatin M also increased intracellular calcium concentrations that act upstream of Akt and ERK. Treatment with Oncostatin M led to the recovery of high-glucose-induced impairment of Akt phosphorylation. Thus, Oncostatin M can protect neuronal cell damage related to high-glucose conditions, showing potential as a therapeutic agent.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalNeuroreport
Volume30
Issue number11
DOIs
Publication statusPublished - 2019 Aug 7

Keywords

  • Akt
  • c-Fos
  • ERK
  • high-glucose
  • Oncostatin M

ASJC Scopus subject areas

  • Neuroscience(all)

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