One for Many

A Universal Reagent for Acylation Processes

Hyun Kyung Moon, Gi Hyeon Sung, Bo Ram Kim, Jong Keun Park, Yong Jin Yoon, Hyo Jae Yoon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This work describes acylation reactions facilitated by a type of heterocycle-based acyl transfer agent, 2-acyloxypyridazinone. Reactions of 2-acyloxypyridazinone with carboxylic acids yield mixed carbonic anhydride intermediates, which are reactive and could be coupled with a wide range of substrates including acids, amines, alcohols, and thiols. The wide substrate scope, ease of operation (no additive or catalyst), storage and handling stability, and atom-efficiency from recycling the heterocycle carrier make the reported acylating agent attractive for acylation-based coupling reactions.

Original languageEnglish
JournalAdvanced Synthesis and Catalysis
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Acylation
Substrates
Carboxylic Acids
Carboxylic acids
Sulfhydryl Compounds
Carbon Dioxide
Amines
Recycling
Alcohols
Atoms
Catalysts
Acids

Keywords

  • 2-alkoxycarbonylpyridazin-3(2H)-ones
  • Acylating agents
  • Coupling reactions
  • Heterocycles
  • Mixed carbonic anhydrides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

One for Many : A Universal Reagent for Acylation Processes. / Moon, Hyun Kyung; Sung, Gi Hyeon; Kim, Bo Ram; Park, Jong Keun; Yoon, Yong Jin; Yoon, Hyo Jae.

In: Advanced Synthesis and Catalysis, 2016.

Research output: Contribution to journalArticle

Moon, Hyun Kyung ; Sung, Gi Hyeon ; Kim, Bo Ram ; Park, Jong Keun ; Yoon, Yong Jin ; Yoon, Hyo Jae. / One for Many : A Universal Reagent for Acylation Processes. In: Advanced Synthesis and Catalysis. 2016.
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