One for Many: A Universal Reagent for Acylation Processes

Hyun Kyung Moon, Gi Hyeon Sung, Bo Ram Kim, Jong Keun Park, Yong Jin Yoon, Hyo Jae Yoon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This work describes acylation reactions facilitated by a type of heterocycle-based acyl transfer agent, 2-acyloxypyridazinone. Reactions of 2-acyloxypyridazinone with carboxylic acids yield mixed carbonic anhydride intermediates, which are reactive and could be coupled with a wide range of substrates including acids, amines, alcohols, and thiols. The wide substrate scope, ease of operation (no additive or catalyst), storage and handling stability, and atom-efficiency from recycling the heterocycle carrier make the reported acylating agent attractive for acylation-based coupling reactions.

Original languageEnglish
JournalAdvanced Synthesis and Catalysis
DOIs
Publication statusAccepted/In press - 2016

Keywords

  • 2-alkoxycarbonylpyridazin-3(2H)-ones
  • Acylating agents
  • Coupling reactions
  • Heterocycles
  • Mixed carbonic anhydrides

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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