One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications

Jiyeon Lee, Gyoyeon Hwang, Yeon Sun Hong, Taebo Sim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dual modal nanoprobes are promising tools for accurately detecting target molecules as part of the diagnosis of diseases including cancers. We have explored a new dual modal bioimaging probe that is comprised of a quantum dot (QD)-magnetic nanoparticle (MNP) hybrid. The MNP-QD heterodimers explored are fabricated by using a platinum-guanine coordination bonding guided self-assembly process, employing the metal-DNA conjugation method. Investigations utilizing energy dispersive spectroscopy (EDS) equipped high resolution transmission electron microscopy (HRTEM) demonstrate that the heterodimer contains an iron (Fe) dominant MNP and a cadmium (Cd) dominant QD. Finally, the results of cell studies show that the MNP-QD conjugates display good HeLa cell uptake in the absence of non-specific binding to the cell membrane and, as such, they can be used to label cells in vitro and in vivo as part of a new cell imaging technique.

Original languageEnglish
Pages (from-to)2864-2868
Number of pages5
JournalAnalyst
Volume140
Issue number8
DOIs
Publication statusPublished - 2015 Apr 21

Fingerprint

Quantum Dots
Nanoparticles
Semiconductor quantum dots
Imaging techniques
Nanoprobes
Guanine
Cell membranes
High resolution transmission electron microscopy
Platinum
Transmission Electron Microscopy
Cadmium
HeLa Cells
platinum
Self assembly
Labels
transmission electron microscopy
Energy dispersive spectroscopy
cancer
Spectrum Analysis
DNA

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

Cite this

One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications. / Lee, Jiyeon; Hwang, Gyoyeon; Hong, Yeon Sun; Sim, Taebo.

In: Analyst, Vol. 140, No. 8, 21.04.2015, p. 2864-2868.

Research output: Contribution to journalArticle

Lee, Jiyeon ; Hwang, Gyoyeon ; Hong, Yeon Sun ; Sim, Taebo. / One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications. In: Analyst. 2015 ; Vol. 140, No. 8. pp. 2864-2868.
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