One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications

Jiyeon Lee, Gyoyeon Hwang, Yeon Sun Hong, Taebo Sim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dual modal nanoprobes are promising tools for accurately detecting target molecules as part of the diagnosis of diseases including cancers. We have explored a new dual modal bioimaging probe that is comprised of a quantum dot (QD)-magnetic nanoparticle (MNP) hybrid. The MNP-QD heterodimers explored are fabricated by using a platinum-guanine coordination bonding guided self-assembly process, employing the metal-DNA conjugation method. Investigations utilizing energy dispersive spectroscopy (EDS) equipped high resolution transmission electron microscopy (HRTEM) demonstrate that the heterodimer contains an iron (Fe) dominant MNP and a cadmium (Cd) dominant QD. Finally, the results of cell studies show that the MNP-QD conjugates display good HeLa cell uptake in the absence of non-specific binding to the cell membrane and, as such, they can be used to label cells in vitro and in vivo as part of a new cell imaging technique.

Original languageEnglish
Pages (from-to)2864-2868
Number of pages5
JournalAnalyst
Volume140
Issue number8
DOIs
Publication statusPublished - 2015 Apr 21

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

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