Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Kiho Park, Do Yeon Kim, Dae Ryook Yang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Continuous multistage mixed suspension and mixed product removal (MSMPR) crystallization processes are useful for the large-scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been completely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of ∼3 is effective in both regions. These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.

Original languageEnglish
Pages (from-to)7142-7153
Number of pages12
JournalIndustrial and Engineering Chemistry Research
Volume55
Issue number26
DOIs
Publication statusPublished - 2016 Jul 6

Fingerprint

Crystallization kinetics
Crystallization
Kinetic parameters
Suspensions
Nucleation
Cooling
Crystallizers
Particle size

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering

Cite this

@article{238f2d4991a34c9cad58cda2afabe297,
title = "Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters",
abstract = "Continuous multistage mixed suspension and mixed product removal (MSMPR) crystallization processes are useful for the large-scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been completely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of ∼3 is effective in both regions. These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.",
author = "Kiho Park and Kim, {Do Yeon} and Yang, {Dae Ryook}",
year = "2016",
month = "7",
day = "6",
doi = "10.1021/acs.iecr.6b01386",
language = "English",
volume = "55",
pages = "7142--7153",
journal = "Industrial and Engineering Chemistry Research",
issn = "0888-5885",
publisher = "American Chemical Society",
number = "26",

}

TY - JOUR

T1 - Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

AU - Park, Kiho

AU - Kim, Do Yeon

AU - Yang, Dae Ryook

PY - 2016/7/6

Y1 - 2016/7/6

N2 - Continuous multistage mixed suspension and mixed product removal (MSMPR) crystallization processes are useful for the large-scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been completely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of ∼3 is effective in both regions. These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.

AB - Continuous multistage mixed suspension and mixed product removal (MSMPR) crystallization processes are useful for the large-scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been completely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of ∼3 is effective in both regions. These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.

UR - http://www.scopus.com/inward/record.url?scp=84978063264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978063264&partnerID=8YFLogxK

U2 - 10.1021/acs.iecr.6b01386

DO - 10.1021/acs.iecr.6b01386

M3 - Article

VL - 55

SP - 7142

EP - 7153

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

SN - 0888-5885

IS - 26

ER -