Operation strategy of industrial crystallization for the production of 2,3,4,4'-tetrahydroxybenzophenon

Do Yeon Kim, Dae Ryook Yang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To improve the filterability of hydroxybenzophenone crystal, a cooling strategy for the cooling crystallization process is investigated by examining the solubility and growth kinetics of hydroxybenzophenone. The operating strategy is divided into two steps. The first step is to generate the seed by dissolving the raw material and by changing operating conditions. The second step is to grow seeds to the product with desired crystal size distribution. For each part, an operating strategy has been proposed based on the solid-liquid phase equilibrium data in a ternary system and growth kinetic experimental results. The strategy for the first step is experimentally determined under various operating conditions, and the second one is determined by theoretical modeling and model-based optimization. The average crystal size resulting from the proposed strategy has been improved and the filterability has been enhanced compared to an existing strategy used in the industry.

Original languageEnglish
Article numberA004
Pages (from-to)1222-1228
Number of pages7
JournalKorean Journal of Chemical Engineering
Volume32
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Crystallization
Growth kinetics
Crystals
Seed
Cooling
Ternary systems
Phase equilibria
Raw materials
Solubility
Liquids
Industry

Keywords

  • Crystallization
  • Operation strategy
  • Optimization
  • Tetrahydroxybenzophenone

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Operation strategy of industrial crystallization for the production of 2,3,4,4'-tetrahydroxybenzophenon. / Kim, Do Yeon; Yang, Dae Ryook.

In: Korean Journal of Chemical Engineering, Vol. 32, No. 7, A004, 01.07.2015, p. 1222-1228.

Research output: Contribution to journalArticle

@article{e15a671c650e488ab7a42f68e7b3a92c,
title = "Operation strategy of industrial crystallization for the production of 2,3,4,4'-tetrahydroxybenzophenon",
abstract = "To improve the filterability of hydroxybenzophenone crystal, a cooling strategy for the cooling crystallization process is investigated by examining the solubility and growth kinetics of hydroxybenzophenone. The operating strategy is divided into two steps. The first step is to generate the seed by dissolving the raw material and by changing operating conditions. The second step is to grow seeds to the product with desired crystal size distribution. For each part, an operating strategy has been proposed based on the solid-liquid phase equilibrium data in a ternary system and growth kinetic experimental results. The strategy for the first step is experimentally determined under various operating conditions, and the second one is determined by theoretical modeling and model-based optimization. The average crystal size resulting from the proposed strategy has been improved and the filterability has been enhanced compared to an existing strategy used in the industry.",
keywords = "Crystallization, Operation strategy, Optimization, Tetrahydroxybenzophenone",
author = "Kim, {Do Yeon} and Yang, {Dae Ryook}",
year = "2015",
month = "7",
day = "1",
doi = "10.1007/s11814-014-0320-z",
language = "English",
volume = "32",
pages = "1222--1228",
journal = "Korean Journal of Chemical Engineering",
issn = "0256-1115",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Operation strategy of industrial crystallization for the production of 2,3,4,4'-tetrahydroxybenzophenon

AU - Kim, Do Yeon

AU - Yang, Dae Ryook

PY - 2015/7/1

Y1 - 2015/7/1

N2 - To improve the filterability of hydroxybenzophenone crystal, a cooling strategy for the cooling crystallization process is investigated by examining the solubility and growth kinetics of hydroxybenzophenone. The operating strategy is divided into two steps. The first step is to generate the seed by dissolving the raw material and by changing operating conditions. The second step is to grow seeds to the product with desired crystal size distribution. For each part, an operating strategy has been proposed based on the solid-liquid phase equilibrium data in a ternary system and growth kinetic experimental results. The strategy for the first step is experimentally determined under various operating conditions, and the second one is determined by theoretical modeling and model-based optimization. The average crystal size resulting from the proposed strategy has been improved and the filterability has been enhanced compared to an existing strategy used in the industry.

AB - To improve the filterability of hydroxybenzophenone crystal, a cooling strategy for the cooling crystallization process is investigated by examining the solubility and growth kinetics of hydroxybenzophenone. The operating strategy is divided into two steps. The first step is to generate the seed by dissolving the raw material and by changing operating conditions. The second step is to grow seeds to the product with desired crystal size distribution. For each part, an operating strategy has been proposed based on the solid-liquid phase equilibrium data in a ternary system and growth kinetic experimental results. The strategy for the first step is experimentally determined under various operating conditions, and the second one is determined by theoretical modeling and model-based optimization. The average crystal size resulting from the proposed strategy has been improved and the filterability has been enhanced compared to an existing strategy used in the industry.

KW - Crystallization

KW - Operation strategy

KW - Optimization

KW - Tetrahydroxybenzophenone

UR - http://www.scopus.com/inward/record.url?scp=84943348266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943348266&partnerID=8YFLogxK

U2 - 10.1007/s11814-014-0320-z

DO - 10.1007/s11814-014-0320-z

M3 - Article

AN - SCOPUS:84943348266

VL - 32

SP - 1222

EP - 1228

JO - Korean Journal of Chemical Engineering

JF - Korean Journal of Chemical Engineering

SN - 0256-1115

IS - 7

M1 - A004

ER -