Opportunistic diseases among HIV-infected patients: A multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013

Youn Jeong Kim, Jun Hee Woo, Ja Kim Min, Dae Won Park, Joon-Young Song, Shin Woo Kim, Jun Yong Choi, June Myung Kim, Sang Hoon Han, Jin Soo Lee, Bo Youl Choi, Joo Shil Lee, Sung Soon Kim, Mee Kyung Kee, Moon Won Kang, Sang Il Kim

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Abstract

Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logistical network to support multicenter projects on epidemiological, clinical, and laboratory aspects of HIV infection. This study evaluated the prevalence of ODs among HIV-infected patients in the era of highly active antiretroviral therapy, and the risk factors associated with ODs. Methods: The study enrolled 1,086 HIV-infected patients from 19 hospitals. This study examined the baseline data of the HIV/AIDS Korean cohort study at the time of enrollment from December 2006 to July 2013. Results: Candidiasis was the most prevalent opportunistic infection (n = 176, 16.2%), followed by Mycobacterium tuberculosis infection (n = 120, 10.9%), Pneumocystis jirovecii pneumonia (n = 121, 11.0%), cytomegalovirus infection (n = 52, 4.7%), and herpes zoster (n = 44, 4.0%). The prevalence rates of Kaposi’s sarcoma (n = 8, 0.7%) and toxoplasmosis (n = 4, 0.4%) were very low compared with other countries. The risk factors for ODs were a low CD4 T cell count at the time of HIV diagnosis (odds ratio [OR], 1.01; p < 0.01), current smoking (OR, 2.27; p = 0.01), current alcohol use (OR, 2.57; p = 0.04), and a history of tuberculosis (OR, 5.23; p < 0.01). Conclusions: Using recent Korean nationwide data, this study demonstrated that an important predictor of ODs was a low CD4 T cell count at the time of HIV diagnosis. Tuberculosis remains one of the most important ODs in HIV-infected patients in Korea.

Original languageEnglish
Pages (from-to)953-960
Number of pages8
JournalKorean Journal of Internal Medicine
Volume31
Issue number5
DOIs
Publication statusPublished - 2016 Sep 1

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Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Odds Ratio
Virus Diseases
CD4 Lymphocyte Count
Korea
Tuberculosis
T-Lymphocytes
Pneumocystis carinii
Mycobacterium Infections
Pneumocystis Pneumonia
Candidiasis
Kaposi's Sarcoma
Toxoplasmosis
Opportunistic Infections
Highly Active Antiretroviral Therapy
Cytomegalovirus Infections
Herpes Zoster
Mycobacterium tuberculosis

Keywords

  • AIDS-related opportunistic infections
  • HIV
  • Korea
  • Tuberculosis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Opportunistic diseases among HIV-infected patients : A multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013. / Kim, Youn Jeong; Woo, Jun Hee; Min, Ja Kim; Park, Dae Won; Song, Joon-Young; Kim, Shin Woo; Choi, Jun Yong; Kim, June Myung; Han, Sang Hoon; Lee, Jin Soo; Choi, Bo Youl; Lee, Joo Shil; Kim, Sung Soon; Kee, Mee Kyung; Kang, Moon Won; Kim, Sang Il.

In: Korean Journal of Internal Medicine, Vol. 31, No. 5, 01.09.2016, p. 953-960.

Research output: Contribution to journalArticle

Kim, YJ, Woo, JH, Min, JK, Park, DW, Song, J-Y, Kim, SW, Choi, JY, Kim, JM, Han, SH, Lee, JS, Choi, BY, Lee, JS, Kim, SS, Kee, MK, Kang, MW & Kim, SI 2016, 'Opportunistic diseases among HIV-infected patients: A multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013', Korean Journal of Internal Medicine, vol. 31, no. 5, pp. 953-960. https://doi.org/10.3904/kjim.2014.322
Kim, Youn Jeong ; Woo, Jun Hee ; Min, Ja Kim ; Park, Dae Won ; Song, Joon-Young ; Kim, Shin Woo ; Choi, Jun Yong ; Kim, June Myung ; Han, Sang Hoon ; Lee, Jin Soo ; Choi, Bo Youl ; Lee, Joo Shil ; Kim, Sung Soon ; Kee, Mee Kyung ; Kang, Moon Won ; Kim, Sang Il. / Opportunistic diseases among HIV-infected patients : A multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013. In: Korean Journal of Internal Medicine. 2016 ; Vol. 31, No. 5. pp. 953-960.
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abstract = "Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logistical network to support multicenter projects on epidemiological, clinical, and laboratory aspects of HIV infection. This study evaluated the prevalence of ODs among HIV-infected patients in the era of highly active antiretroviral therapy, and the risk factors associated with ODs. Methods: The study enrolled 1,086 HIV-infected patients from 19 hospitals. This study examined the baseline data of the HIV/AIDS Korean cohort study at the time of enrollment from December 2006 to July 2013. Results: Candidiasis was the most prevalent opportunistic infection (n = 176, 16.2{\%}), followed by Mycobacterium tuberculosis infection (n = 120, 10.9{\%}), Pneumocystis jirovecii pneumonia (n = 121, 11.0{\%}), cytomegalovirus infection (n = 52, 4.7{\%}), and herpes zoster (n = 44, 4.0{\%}). The prevalence rates of Kaposi’s sarcoma (n = 8, 0.7{\%}) and toxoplasmosis (n = 4, 0.4{\%}) were very low compared with other countries. The risk factors for ODs were a low CD4 T cell count at the time of HIV diagnosis (odds ratio [OR], 1.01; p < 0.01), current smoking (OR, 2.27; p = 0.01), current alcohol use (OR, 2.57; p = 0.04), and a history of tuberculosis (OR, 5.23; p < 0.01). Conclusions: Using recent Korean nationwide data, this study demonstrated that an important predictor of ODs was a low CD4 T cell count at the time of HIV diagnosis. Tuberculosis remains one of the most important ODs in HIV-infected patients in Korea.",
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T2 - A multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013

AU - Kim, Youn Jeong

AU - Woo, Jun Hee

AU - Min, Ja Kim

AU - Park, Dae Won

AU - Song, Joon-Young

AU - Kim, Shin Woo

AU - Choi, Jun Yong

AU - Kim, June Myung

AU - Han, Sang Hoon

AU - Lee, Jin Soo

AU - Choi, Bo Youl

AU - Lee, Joo Shil

AU - Kim, Sung Soon

AU - Kee, Mee Kyung

AU - Kang, Moon Won

AU - Kim, Sang Il

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N2 - Background/Aims: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logistical network to support multicenter projects on epidemiological, clinical, and laboratory aspects of HIV infection. This study evaluated the prevalence of ODs among HIV-infected patients in the era of highly active antiretroviral therapy, and the risk factors associated with ODs. Methods: The study enrolled 1,086 HIV-infected patients from 19 hospitals. This study examined the baseline data of the HIV/AIDS Korean cohort study at the time of enrollment from December 2006 to July 2013. Results: Candidiasis was the most prevalent opportunistic infection (n = 176, 16.2%), followed by Mycobacterium tuberculosis infection (n = 120, 10.9%), Pneumocystis jirovecii pneumonia (n = 121, 11.0%), cytomegalovirus infection (n = 52, 4.7%), and herpes zoster (n = 44, 4.0%). The prevalence rates of Kaposi’s sarcoma (n = 8, 0.7%) and toxoplasmosis (n = 4, 0.4%) were very low compared with other countries. The risk factors for ODs were a low CD4 T cell count at the time of HIV diagnosis (odds ratio [OR], 1.01; p < 0.01), current smoking (OR, 2.27; p = 0.01), current alcohol use (OR, 2.57; p = 0.04), and a history of tuberculosis (OR, 5.23; p < 0.01). Conclusions: Using recent Korean nationwide data, this study demonstrated that an important predictor of ODs was a low CD4 T cell count at the time of HIV diagnosis. Tuberculosis remains one of the most important ODs in HIV-infected patients in Korea.

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