Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa

Young Hoon Hwang, Seong-Woo Kim, Yong Yeon Kim, Jung Hwa Na, Hwang Ki Kim, Yong Ho Sohn

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: To evaluate optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness by using Cirrus HD spectral-domain optical coherence tomography (OCT) in young patients with retinitis pigmentosa (RP). Methods: ONH parameters, RNFL thickness, and macular thickness were measured and compared between 36 eyes from 36 young RP patients (RP group; mean age, 23.08 years) and 70 eyes from 70 healthy young subjects (control group; mean age, 22.66 years) using Cirrus HD-OCT. The effects of the presence of optic disc pallor and the severity of visual field (VF) defects on OCT parameters were also evaluated. Results: The RP group had a greater rim area, smaller cup-to-disc ratio, smaller cup volume, thicker RNFL, and thinner macula than the control group (p ≤ 0.024). ONH parameters were not affected by the presence of optic disc pallor (p ≥ 0.239). Eyes with more severe VF defects (mean deviation ≤ -13.88 dB) had thinner average macular areas than eyes with less severe VF defects (mean deviation ≥ -13.88 dB; p = 0.002). Meanwhile, the ONH parameters and average peripapillary RNFL thickness were not significantly different between the two groups (p ≥ 0.275). Conclusions: Young eyes with RP exhibited different OCT parameters compared to healthy eyes. Among the various OCT parameters, only macular thickness was associated with disease severity. These findings should be considered when evaluating young RP patients.

Original languageEnglish
Pages (from-to)914-920
Number of pages7
JournalCurrent Eye Research
Volume37
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Retinitis Pigmentosa
Optic Disk
Nerve Fibers
Optical Coherence Tomography
Visual Fields
Pallor
Control Groups
Healthy Volunteers

Keywords

  • Glaucoma
  • Optic nerve head
  • Optical coherence tomography
  • Retinal nerve fiber layer
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa. / Hwang, Young Hoon; Kim, Seong-Woo; Kim, Yong Yeon; Na, Jung Hwa; Kim, Hwang Ki; Sohn, Yong Ho.

In: Current Eye Research, Vol. 37, No. 10, 01.10.2012, p. 914-920.

Research output: Contribution to journalArticle

@article{f3ac30c070274cdcb87537daaf78d0cd,
title = "Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa",
abstract = "Purpose: To evaluate optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness by using Cirrus HD spectral-domain optical coherence tomography (OCT) in young patients with retinitis pigmentosa (RP). Methods: ONH parameters, RNFL thickness, and macular thickness were measured and compared between 36 eyes from 36 young RP patients (RP group; mean age, 23.08 years) and 70 eyes from 70 healthy young subjects (control group; mean age, 22.66 years) using Cirrus HD-OCT. The effects of the presence of optic disc pallor and the severity of visual field (VF) defects on OCT parameters were also evaluated. Results: The RP group had a greater rim area, smaller cup-to-disc ratio, smaller cup volume, thicker RNFL, and thinner macula than the control group (p ≤ 0.024). ONH parameters were not affected by the presence of optic disc pallor (p ≥ 0.239). Eyes with more severe VF defects (mean deviation ≤ -13.88 dB) had thinner average macular areas than eyes with less severe VF defects (mean deviation ≥ -13.88 dB; p = 0.002). Meanwhile, the ONH parameters and average peripapillary RNFL thickness were not significantly different between the two groups (p ≥ 0.275). Conclusions: Young eyes with RP exhibited different OCT parameters compared to healthy eyes. Among the various OCT parameters, only macular thickness was associated with disease severity. These findings should be considered when evaluating young RP patients.",
keywords = "Glaucoma, Optic nerve head, Optical coherence tomography, Retinal nerve fiber layer, Retinitis pigmentosa",
author = "Hwang, {Young Hoon} and Seong-Woo Kim and Kim, {Yong Yeon} and Na, {Jung Hwa} and Kim, {Hwang Ki} and Sohn, {Yong Ho}",
year = "2012",
month = "10",
day = "1",
doi = "10.3109/02713683.2012.688163",
language = "English",
volume = "37",
pages = "914--920",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Informa Healthcare",
number = "10",

}

TY - JOUR

T1 - Optic nerve head, retinal nerve fiber layer, and macular thickness measurements in young patients with retinitis pigmentosa

AU - Hwang, Young Hoon

AU - Kim, Seong-Woo

AU - Kim, Yong Yeon

AU - Na, Jung Hwa

AU - Kim, Hwang Ki

AU - Sohn, Yong Ho

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Purpose: To evaluate optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness by using Cirrus HD spectral-domain optical coherence tomography (OCT) in young patients with retinitis pigmentosa (RP). Methods: ONH parameters, RNFL thickness, and macular thickness were measured and compared between 36 eyes from 36 young RP patients (RP group; mean age, 23.08 years) and 70 eyes from 70 healthy young subjects (control group; mean age, 22.66 years) using Cirrus HD-OCT. The effects of the presence of optic disc pallor and the severity of visual field (VF) defects on OCT parameters were also evaluated. Results: The RP group had a greater rim area, smaller cup-to-disc ratio, smaller cup volume, thicker RNFL, and thinner macula than the control group (p ≤ 0.024). ONH parameters were not affected by the presence of optic disc pallor (p ≥ 0.239). Eyes with more severe VF defects (mean deviation ≤ -13.88 dB) had thinner average macular areas than eyes with less severe VF defects (mean deviation ≥ -13.88 dB; p = 0.002). Meanwhile, the ONH parameters and average peripapillary RNFL thickness were not significantly different between the two groups (p ≥ 0.275). Conclusions: Young eyes with RP exhibited different OCT parameters compared to healthy eyes. Among the various OCT parameters, only macular thickness was associated with disease severity. These findings should be considered when evaluating young RP patients.

AB - Purpose: To evaluate optic nerve head (ONH) parameters, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness by using Cirrus HD spectral-domain optical coherence tomography (OCT) in young patients with retinitis pigmentosa (RP). Methods: ONH parameters, RNFL thickness, and macular thickness were measured and compared between 36 eyes from 36 young RP patients (RP group; mean age, 23.08 years) and 70 eyes from 70 healthy young subjects (control group; mean age, 22.66 years) using Cirrus HD-OCT. The effects of the presence of optic disc pallor and the severity of visual field (VF) defects on OCT parameters were also evaluated. Results: The RP group had a greater rim area, smaller cup-to-disc ratio, smaller cup volume, thicker RNFL, and thinner macula than the control group (p ≤ 0.024). ONH parameters were not affected by the presence of optic disc pallor (p ≥ 0.239). Eyes with more severe VF defects (mean deviation ≤ -13.88 dB) had thinner average macular areas than eyes with less severe VF defects (mean deviation ≥ -13.88 dB; p = 0.002). Meanwhile, the ONH parameters and average peripapillary RNFL thickness were not significantly different between the two groups (p ≥ 0.275). Conclusions: Young eyes with RP exhibited different OCT parameters compared to healthy eyes. Among the various OCT parameters, only macular thickness was associated with disease severity. These findings should be considered when evaluating young RP patients.

KW - Glaucoma

KW - Optic nerve head

KW - Optical coherence tomography

KW - Retinal nerve fiber layer

KW - Retinitis pigmentosa

UR - http://www.scopus.com/inward/record.url?scp=84865730812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865730812&partnerID=8YFLogxK

U2 - 10.3109/02713683.2012.688163

DO - 10.3109/02713683.2012.688163

M3 - Article

C2 - 22738608

AN - SCOPUS:84865730812

VL - 37

SP - 914

EP - 920

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 10

ER -