Optical detection of red blood cell aggregation in a disposable microfluidic channel

Sehyun Shin, Ju Hee Jang, Myung Soo Park, Yunhee Ku, Jang Soo Suh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aggregability of red blood cells (RBCs) was determined by laser backscattering light analysis in a microfluidic channel. Available techniques for RBC aggregation often adopt a rotational Couette-flow using a bob-and-cup system for disaggregating RBCs, which causes the system to be complex and expensive. A disposable microfluidic channel and vibration generating mechanism were used in the proposed new detection system for RBC aggregation. Prior to measurement, RBC aggregates in a blood sample were completely disaggregated by the application of vibration-induced shear. With the present apparatus, the aggregation indexes of RBCs can be measured easily with small quantities of a blood sample. The measurements with the present aggregometer were compared with those of LORCA and the results showed a strong correlation between them. The aggregability of the defibrinogenated blood RBCs is markedly lower than that of the normal RBCs. The noble feature of this design is the vibration-induced disaggregation mechanism, which can incorporate the disposable element that holds the blood sample.

Original languageEnglish
Pages (from-to)887-893
Number of pages7
JournalJournal of Mechanical Science and Technology
Volume19
Issue number3
Publication statusPublished - 2005 Mar 1
Externally publishedYes

Keywords

  • Aggregation
  • Light-Backscattering
  • Red Blood Cell
  • Vibration

ASJC Scopus subject areas

  • Mechanical Engineering

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