Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography

Sang Won Lee, Ji Yeong Yoo, Jin Ho Kang, Moon Sik Kang, Soon Hee Jung, Yosep Chong, Dong Su Cha, Kyung Hee Han, Beop-Min Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of our PS-OCT system are 13 μm and 15 μm, respectively. Uterine cervical conization tissue samples from 18 patients were examined, and 71 areas were imaged for in vitro studies; about 2-4 areas per sample were imaged and processed for diagnosis. The scanned areas had a size of 2 mm (axial) × 2 mm (lateral) × 4 mm (transversal). We quantified the slope of the axial decay of the DOCP signal near the cervical epithelium by a linear fitting procedure. The excised samples were then investigated by two pathologists, and their histological findings were later compared with the PS-OCT results. Our results show that the sensitivity and specificity are 94.7% and 71.2%, respectively.

Original languageEnglish
Pages (from-to)2709-2719
Number of pages11
JournalOptics Express
Volume16
Issue number4
DOIs
Publication statusPublished - 2008 Feb 18
Externally publishedYes

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neoplasms
tomography
polarization
circular polarization
epithelium
slopes
sensitivity
decay
scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography. / Lee, Sang Won; Yoo, Ji Yeong; Kang, Jin Ho; Kang, Moon Sik; Jung, Soon Hee; Chong, Yosep; Cha, Dong Su; Han, Kyung Hee; Kim, Beop-Min.

In: Optics Express, Vol. 16, No. 4, 18.02.2008, p. 2709-2719.

Research output: Contribution to journalArticle

Lee, Sang Won ; Yoo, Ji Yeong ; Kang, Jin Ho ; Kang, Moon Sik ; Jung, Soon Hee ; Chong, Yosep ; Cha, Dong Su ; Han, Kyung Hee ; Kim, Beop-Min. / Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography. In: Optics Express. 2008 ; Vol. 16, No. 4. pp. 2709-2719.
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AU - Jung, Soon Hee

AU - Chong, Yosep

AU - Cha, Dong Su

AU - Han, Kyung Hee

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