Abstract
We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of our PS-OCT system are 13 μm and 15 μm, respectively. Uterine cervical conization tissue samples from 18 patients were examined, and 71 areas were imaged for in vitro studies; about 2-4 areas per sample were imaged and processed for diagnosis. The scanned areas had a size of 2 mm (axial) × 2 mm (lateral) × 4 mm (transversal). We quantified the slope of the axial decay of the DOCP signal near the cervical epithelium by a linear fitting procedure. The excised samples were then investigated by two pathologists, and their histological findings were later compared with the PS-OCT results. Our results show that the sensitivity and specificity are 94.7% and 71.2%, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 2709-2719 |
| Number of pages | 11 |
| Journal | Optics Express |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2008 Feb 18 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography. / Lee, Sang Won; Yoo, Ji Yeong; Kang, Jin Ho; Kang, Moon Sik; Jung, Soon Hee; Chong, Yosep; Cha, Dong Su; Han, Kyung Hee; Kim, Beop-Min.
In: Optics Express, Vol. 16, No. 4, 18.02.2008, p. 2709-2719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography
AU - Lee, Sang Won
AU - Yoo, Ji Yeong
AU - Kang, Jin Ho
AU - Kang, Moon Sik
AU - Jung, Soon Hee
AU - Chong, Yosep
AU - Cha, Dong Su
AU - Han, Kyung Hee
AU - Kim, Beop-Min
PY - 2008/2/18
Y1 - 2008/2/18
N2 - We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of our PS-OCT system are 13 μm and 15 μm, respectively. Uterine cervical conization tissue samples from 18 patients were examined, and 71 areas were imaged for in vitro studies; about 2-4 areas per sample were imaged and processed for diagnosis. The scanned areas had a size of 2 mm (axial) × 2 mm (lateral) × 4 mm (transversal). We quantified the slope of the axial decay of the DOCP signal near the cervical epithelium by a linear fitting procedure. The excised samples were then investigated by two pathologists, and their histological findings were later compared with the PS-OCT results. Our results show that the sensitivity and specificity are 94.7% and 71.2%, respectively.
AB - We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by the scattering changes induced by cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions of our PS-OCT system are 13 μm and 15 μm, respectively. Uterine cervical conization tissue samples from 18 patients were examined, and 71 areas were imaged for in vitro studies; about 2-4 areas per sample were imaged and processed for diagnosis. The scanned areas had a size of 2 mm (axial) × 2 mm (lateral) × 4 mm (transversal). We quantified the slope of the axial decay of the DOCP signal near the cervical epithelium by a linear fitting procedure. The excised samples were then investigated by two pathologists, and their histological findings were later compared with the PS-OCT results. Our results show that the sensitivity and specificity are 94.7% and 71.2%, respectively.
UR - http://www.scopus.com/inward/record.url?scp=39749094442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749094442&partnerID=8YFLogxK
U2 - 10.1364/OE.16.002709
DO - 10.1364/OE.16.002709
M3 - Article
C2 - 18542356
AN - SCOPUS:39749094442
VL - 16
SP - 2709
EP - 2719
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 4
ER -