Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen

Hyun Soo Jang, Kwang No Park, Chang Duk Kang, Jun Pyo Kim, Sang Jun Sim, Kyung Shik Lee

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

We present a new, sensitive, few mode fiber (FMF) surface plasmon resonance (SPR) biosensor with a sandwich assay for the detection of PSA. The side-polished FMF biosensor does not need a polarizer and a thin high-index overlayer. The optical sensitivity of the SPR sensor was determined as 2.5 × 10-6 RIU. In the SPR PSA sensor, the SPR signals were amplified by a factor of 6 in average over no secondary antibody, using the sandwich assay. The proposed FMF SPR biosensor has great potential for real-time analysis of immune reaction between biomolecules and the advantages of high-sensitivity and label-free detection.

Original languageEnglish
Pages (from-to)2827-2830
Number of pages4
JournalOptics Communications
Volume282
Issue number14
DOIs
Publication statusPublished - 2009 Jul 15
Externally publishedYes

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Keywords

  • Biosensor
  • Detection
  • Optical fiber sensor
  • Surface plasmon resonance (SPR)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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