Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen

Hyun Soo Jang, Kwang No Park, Chang Duk Kang, Jun Pyo Kim, Sang Jun Sim, Kyung Shik Lee

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We present a new, sensitive, few mode fiber (FMF) surface plasmon resonance (SPR) biosensor with a sandwich assay for the detection of PSA. The side-polished FMF biosensor does not need a polarizer and a thin high-index overlayer. The optical sensitivity of the SPR sensor was determined as 2.5 × 10-6 RIU. In the SPR PSA sensor, the SPR signals were amplified by a factor of 6 in average over no secondary antibody, using the sandwich assay. The proposed FMF SPR biosensor has great potential for real-time analysis of immune reaction between biomolecules and the advantages of high-sensitivity and label-free detection.

Original languageEnglish
Pages (from-to)2827-2830
Number of pages4
JournalOptics Communications
Volume282
Issue number14
DOIs
Publication statusPublished - 2009 Jul 15
Externally publishedYes

Fingerprint

Surface plasmon resonance
antigens
Prostate-Specific Antigen
Antigens
bioinstrumentation
surface plasmon resonance
Biosensors
Optical fibers
Assays
optical fibers
fibers
Fibers
Antigen-antibody reactions
sensitivity
sensors
Sensors
Biomolecules
polarizers
antibodies
Antibodies

Keywords

  • Biosensor
  • Detection
  • Optical fiber sensor
  • Surface plasmon resonance (SPR)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

Cite this

Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen. / Jang, Hyun Soo; Park, Kwang No; Kang, Chang Duk; Kim, Jun Pyo; Sim, Sang Jun; Lee, Kyung Shik.

In: Optics Communications, Vol. 282, No. 14, 15.07.2009, p. 2827-2830.

Research output: Contribution to journalArticle

Jang, Hyun Soo ; Park, Kwang No ; Kang, Chang Duk ; Kim, Jun Pyo ; Sim, Sang Jun ; Lee, Kyung Shik. / Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen. In: Optics Communications. 2009 ; Vol. 282, No. 14. pp. 2827-2830.
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