@article{1138bab6c13b4d92b08c006da4d42d80,
title = "Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix",
abstract = "Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are invasive, bulky, and linked to increased incidence of infection at the tissue–device interface. Thus, researchers have looked to other more biocompatible methods for cardiac pacing or resynchronization, such as femtosecond infrared light pulsing, optogenetics, and polymer-based cardiac patches integrated with metal electrodes. Here we develop a biocompatible nongenetic approach for the optical modulation of cardiac cells and tissues. We demonstrate that a polymer–silicon nanowire composite mesh can be used to convert fast moving, low-radiance optical inputs into stimulatory signals in target cardiac cells. Our method allows for the stimulation of the cultured cardiomyocytes or ex vivo heart to beat at a higher target frequency.",
keywords = "Cardiac, Modulation, Nanowire, Optical, Silicon",
author = "Ramya Parameswaran and Kelliann Koehler and Rotenberg, {Menahem Y.} and Burke, {Michael J.} and Jungkil Kim and Jeong, {Kwang Yong} and Barbara Hissa and Paul, {Michael D.} and Kiela Moreno and Nivedina Sarma and Thomas Hayes and Edward Sudzilovsky and Park, {Hong Gyu} and Bozhi Tian",
note = "Funding Information: ACKNOWLEDGMENTS. We thank The University of Chicago Integrated Light Microscopy Core Facility, especially Dr. Christine Labno, for their resources and advice regarding optical stimulation experiments. We thank The University of Chicago Materials Research Science and Engineering Centers, The University of Chicago Searle Cleanroom, and Argonne National Laboratory Center for Nanoscale Materials for their facilities and advice regarding material characterization and fabrication. We also thank The University of Chicago Human Tissue Resource Center for cryosectioning heart tissue for our phototoxicity experiments. We additionally thank Dr. Margaret Gardel for her advice on the in vitro cardiomyocyte optical stimulation experiments. The work was supported by the Air Force Office of Scientific Research (AFOSR FA9550-18-1-0503) and the Office of Naval Research (ONR Young Investigator Program, N000141612530; Presidential Early Career Award for Scientists and Engineers, N000141612958). R.P. acknowledges support from the Paul and Daisy Soros Foundation, NIH F30AI138156-02 Fellowship, and the NIH Medical Scientist Training Program training Grant T32GM007281. B.T. also acknowledges NIH (1DP2NS101488) and Army Research Office (W911NF-18-1-0042). H.-G.P. acknowledges support from National Research Foundation of Korea (NRF) grants funded by the Korean government (Ministry of Science and ICT) (2018R1A3A3000666 and 2017R1A4A1015426). Funding Information: We thank The University of Chicago Integrated Light Microscopy Core Facility, especially Dr. Christine Labno, for their resources and advice regarding optical stimulation experiments. We thank The University of Chicago Materials Research Science and Engineering Centers, The University of Chicago Searle Cleanroom, and Argonne National Laboratory Center for Nanoscale Materials for their facilities and advice regarding material characterization and fabrication. We also thank The University of Chicago Human Tissue Resource Center for cryosectioning heart tissue for our phototoxicity experiments. We additionally thank Dr. Margaret Gardel for her advice on the in vitro cardiomyocyte optical stimulation experiments. The work was supported by the Air Force Office of Scientific Research (AFOSR FA9550-18-1-0503) and the Office of Naval Research (ONR Young Investigator Program, N000141612530; Presidential Early Career Award for Scientists and Engineers, N000141612958). R.P. acknowledges support from the Paul and Daisy Soros Foundation, NIH F30AI138156-02 Fellowship, and the NIH Medical Scientist Training Program training Grant T32GM007281. B.T. also acknowledges NIH (1DP2NS101488) and Army Research Office (W911NF-18-1-0042). H.-G.P. acknowledges support from National Research Foundation of Korea (NRF) grants funded by the Korean government (Ministry of Science and ICT) (2018R1A3A3000666 and 2017R1A4A1015426). Publisher Copyright: {\textcopyright} 2019 National Academy of Sciences. All Rights Reserved.",
year = "2019",
month = jan,
day = "8",
doi = "10.1073/pnas.1816428115",
language = "English",
volume = "116",
pages = "413--421",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "2",
}