Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix

Ramya Parameswaran, Kelliann Koehler, Menahem Y. Rotenberg, Michael J. Burke, Jungkil Kim, Kwang Yong Jeong, Barbara Hissa, Michael D. Paul, Kiela Moreno, Nivedina Sarma, Thomas Hayes, Edward Sudzilovsky, Hong Gyu Park, Bozhi Tian

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are invasive, bulky, and linked to increased incidence of infection at the tissue–device interface. Thus, researchers have looked to other more biocompatible methods for cardiac pacing or resynchronization, such as femtosecond infrared light pulsing, optogenetics, and polymer-based cardiac patches integrated with metal electrodes. Here we develop a biocompatible nongenetic approach for the optical modulation of cardiac cells and tissues. We demonstrate that a polymer–silicon nanowire composite mesh can be used to convert fast moving, low-radiance optical inputs into stimulatory signals in target cardiac cells. Our method allows for the stimulation of the cultured cardiomyocytes or ex vivo heart to beat at a higher target frequency.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number2
DOIs
Publication statusPublished - 2019 Jan 8

Keywords

  • Cardiac
  • Modulation
  • Nanowire
  • Optical
  • Silicon

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix'. Together they form a unique fingerprint.

  • Cite this

    Parameswaran, R., Koehler, K., Rotenberg, M. Y., Burke, M. J., Kim, J., Jeong, K. Y., Hissa, B., Paul, M. D., Moreno, K., Sarma, N., Hayes, T., Sudzilovsky, E., Park, H. G., & Tian, B. (2019). Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix. Proceedings of the National Academy of Sciences of the United States of America, 116(2), 413-421. https://doi.org/10.1073/pnas.1816428115