Optical transfer function of time-gated coherent imaging in the presence of a scattering medium

PILSUNG KANG, SUNGSAM KANG, YONGHYEON JO, HAKSEOK KO, GUANGHOON KIM, YE RYOUNG LEE, WONSHIK CHOI

Research output: Contribution to journalArticlepeer-review

Abstract

Optical imaging of objects embedded within scattering media such as biological tissues suffers from the loss of resolving power. In our previous work, we proposed an approach called collective accumulation of single scattering (CASS) microscopy that attenuates this detrimental effect of multiple light scattering by combining the time-gated detection and spatial input-output correlation. In the present work, we perform a rigorous theoretical analysis on the effect of multiple light scattering to the optical transfer function of CASS microscopy. In particular, the spatial frequency-dependent signal to noise ratio (SNR) is derived depending on the intensity ratio of the single- and multiple-scattered waves. This allows us to determine the depth-dependent resolving power. We conducted experiments using a Siemens star-like target having various spatial frequency components and supported the theoretical derived SNR spectra. Our study provides a theoretical framework for understanding the effect of multiple light scattering in high-resolution and deep-tissue optical imaging.

Original languageEnglish
Pages (from-to)3395-3405
Number of pages11
JournalOptics Express
Volume29
Issue number3
DOIs
Publication statusPublished - 2021 Feb 1

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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