Optimal level of continuous positive airway pressure: Auto-adjusting titration versus titration with a predictive equation

Seung Hoon Lee, Ji Ho Choi, Young Joon Jun, Jeong In Oh, Jong Yoon Jung, Gyu Ho Hwang, Soon Young Kwon, Heung Man Lee, Tae-Hoon Kim, Sang Hag Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)


Objectives: The aims of the present study were twofold. We sought to compare two methods of titrating the level of continuous positive airway pressure (CPAP)-auto-adjusting titration and titration using a predictive equation-with full-night manual titration used as the benchmark. We also investigated the reliability of the two methods in patients with obstructive sleep apnea syndrome (OSAS). Methods: Twenty consecutive adult patients with OSAS who had successful, full-night manual and auto-adjusting CPAP titration participated in this study. The titration pressure level was calculated with a previously developed predictive equation based on body mass index and apnea-hypopnea index. Results: The mean titration pressure levels obtained with the manual, auto-adjusting, and predictive equation methods were 9.0 ± 3.6, 9.4 ± 3.0, and 8.1 ± 1.6 cm H2O, respectively. There was a significant difference in the concordance within the range of ±2 cm H2O (p = 0.019) between both the auto-adjusting titration and the titration using the predictive equation compared to the full-night manual titration. However, there was no significant difference in the concordance within the range of ±1 cm H2O (p > 0.999). Conclusions: When compared to full-night manual titration as the standard method, auto-adjusting titration appears to be more reliable than using a predictive equation for determining the optimal CPAP level in patients with OSAS.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Issue number5
Publication statusPublished - 2013 May 1



  • Adult
  • Body Mass Index
  • Continuous Positive Airway Pressure
  • Obstructive Sleep Apnea Syndrome
  • Polysomnography

ASJC Scopus subject areas

  • Otorhinolaryngology

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