Optimal PET acquisition setting of I-124 with Siemens Inveon PET: Comparative simulation study with F-18 and microPET R4

A. Ram Yu, Jin Su Kim, Kyeong Min Kim, Young Sub Lee, Sang Keun Woo, Won Ho Lee, Jong Guk Kim, Ji Ae Park, Hee Joung Kim, Gi Jeong Cheon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Purpose: I-124 has a long half life of 4.2 days that is suitable for imaging over several days during the biological uptake and washout of radioiodine. However 1-124 has a low positron branching ratio (23%). High-energy y- photons (602 keV to 1,326 keV) are emitted in cascade with the positrons. These cascade γ- photons degrade the image quality. In this study, noise equivalent count rate (NECR) was measured with the various energy window settings to find the optimal energy window setting in 1-124 PET on newly released Siemens Inveon PET. Sensitivity and scatter fraction (SF) on Inveon PET were also assessed with the same energy windows. In addition, NECRs of 1-124 on microPET R4 (R4) scanner were also assessed for the comparison. Methods: Monte Carlo simulation studies were performed to find the optimal energy window setting. System performance such as the sensitivity and scatter fraction was measured in both 1-124 and 18F. NEMA NU-4 rat phantom and mouse phantom were simulated. Source activity was 1 MBq to 150 MBq. NECR in I-124 PET was calculated as following equation: NECR = T2 / (T + S + 2fR + fD) Where, T, S, R, D, and f is dirty coincidence corrected true, scatter, random, dirty coincidence count rate, and average fraction of the projection taken up by the object. Simulation for NECR were repeated under four different conditions (energy window: 250-550, 250-650, 350-550 and 350-650 keV). Results and Discussion: Within an energy window of 350-550 keV, dirty coincidence fraction was dramatically reduced by 50% on Inveon. Comparing two microPET systems, Inveon has 10 times higher NECR than those of R4. This would be due to improved electronics which enable to minimize the system dead time. Considering NECR of I-124, optimal energy window was 250-650 and 350-550 keV for mouse and rat, respectively. The proposed optimal energy window setting would boost the image quality of I-124 PET.

Original languageEnglish
Title of host publication2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
Pages2666-2668
Number of pages3
DOIs
Publication statusPublished - 2009 Dec 1
Externally publishedYes
Event2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 - Orlando, FL, United States
Duration: 2009 Oct 252009 Oct 31

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
CountryUnited States
CityOrlando, FL
Period09/10/2509/10/31

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ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Yu, A. R., Kim, J. S., Kim, K. M., Lee, Y. S., Woo, S. K., Lee, W. H., Kim, J. G., Park, J. A., Kim, H. J., & Cheon, G. J. (2009). Optimal PET acquisition setting of I-124 with Siemens Inveon PET: Comparative simulation study with F-18 and microPET R4. In 2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 (pp. 2666-2668). [5401991] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2009.5401991