Optimal standing-wave design of nonlinear simulated moving bed systems for enantioseparation

Ki Bong Lee, Sungyong Mun, Fattaneh Cauley, Geoffrey B. Cox, Nien Hwa Linda Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An efficient optimization tool is developed based on the standing-wave design for simulated moving bed (SMB) systems with nonlinear isotherms and significant mass-transfer effects. A maximum operating pressure is considered in the optimization. Both system parameters (particle size, column length, column diameter, total number of columns, column configuration, and feed concentration) and operating parameters (zone flow rates and switching time) are optimized to achieve the maximum productivity or the minimum separation cost. Under a pressure limit, medium particle size (10-40μm), short columns (5-15 cm), and a longer zone II give higher productivity and lower separation cost. Nonlinear effects resulting from high feed concentration can decrease productivity and increase separation cost. High-pressure SMB systems (5.2 MPa) can have higher productivity, but low- and medium-pressure SMB systems (1.0 and 2.4 MPa, respectively) are more economical.

Original languageEnglish
Pages (from-to)739-752
Number of pages14
JournalIndustrial and Engineering Chemistry Research
Volume45
Issue number2
DOIs
Publication statusPublished - 2006 Jan 18
Externally publishedYes

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standing wave
Productivity
productivity
Particle size
Costs
particle size
cost
Isotherms
Mass transfer
Flow rate
mass transfer
isotherm
parameter
effect

ASJC Scopus subject areas

  • Polymers and Plastics
  • Environmental Science(all)
  • Chemical Engineering (miscellaneous)

Cite this

Optimal standing-wave design of nonlinear simulated moving bed systems for enantioseparation. / Lee, Ki Bong; Mun, Sungyong; Cauley, Fattaneh; Cox, Geoffrey B.; Wang, Nien Hwa Linda.

In: Industrial and Engineering Chemistry Research, Vol. 45, No. 2, 18.01.2006, p. 739-752.

Research output: Contribution to journalArticle

Lee, Ki Bong ; Mun, Sungyong ; Cauley, Fattaneh ; Cox, Geoffrey B. ; Wang, Nien Hwa Linda. / Optimal standing-wave design of nonlinear simulated moving bed systems for enantioseparation. In: Industrial and Engineering Chemistry Research. 2006 ; Vol. 45, No. 2. pp. 739-752.
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