Optimization of feed conditions in a 2.5-l fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25

Ri Kim Na, Soo Lim Jung, In Hong Suk, Seung Wook Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)


Rice oil significantly affected cephalosporin C production in a 2.5-l bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-l fed-batch culture, cephalosporin C production increased about four times compared to before optimization.

Original languageEnglish
Pages (from-to)787-789
Number of pages3
JournalWorld Journal of Microbiology and Biotechnology
Issue number5
Publication statusPublished - 2005 Jul 1



  • Cephalosporin C
  • Cephalosporium acremonium
  • Fed-batch
  • Feed conditions
  • Rice oil

ASJC Scopus subject areas

  • Food Science
  • Plant Science
  • Biochemistry
  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology

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