Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals

Seungjong Yeom, Huichan Yun, Dae Ryook Yang

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l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.

Original languageEnglish
Pages (from-to)1836-1842
Number of pages7
JournalKorean Journal of Chemical Engineering
Issue number10
Publication statusPublished - 2013 Oct 1



  • Cooling Crystallization
  • l-Glutamic Acid
  • Optimization
  • Polymorphic Transformation
  • Population Balance Model

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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