Abstract
l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.
| Original language | English |
|---|---|
| Pages (from-to) | 1836-1842 |
| Number of pages | 7 |
| Journal | Korean Journal of Chemical Engineering |
| Volume | 30 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2013 Oct 1 |
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Keywords
- Cooling Crystallization
- l-Glutamic Acid
- Optimization
- Polymorphic Transformation
- Population Balance Model
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals. / Yeom, Seungjong; Yun, Huichan; Yang, Dae Ryook.
In: Korean Journal of Chemical Engineering, Vol. 30, No. 10, 01.10.2013, p. 1836-1842.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimization of temperature swing strategy for selective cooling crystallization of α-form l-glutamic acid crystals
AU - Yeom, Seungjong
AU - Yun, Huichan
AU - Yang, Dae Ryook
PY - 2013/10/1
Y1 - 2013/10/1
N2 - l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.
AB - l-glutamic acid can be crystallized as metastable α-form and stable β-form crystal. The α-form is desired because of its prismatic shape. Production of α-form of l-glutamic acid by cooling crystallization is not well-defined and α-form solid is commercially not available. In this study, an optimal cooling strategy to selectively produce large and narrowly distributed α-crystals is found by modeling and optimizing the crystallization and polymorphic transformation of l-glutamic acid. The optimal temperature profile is found to be cooling-heating-cooling concept where short nucleation period is followed by growth period in metastable zone. The obtained α-form of L-glutamic acid by optimal strategy had improved mean size, distribution, and purity compared to constant cooling.
KW - Cooling Crystallization
KW - l-Glutamic Acid
KW - Optimization
KW - Polymorphic Transformation
KW - Population Balance Model
UR - http://www.scopus.com/inward/record.url?scp=84884982003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884982003&partnerID=8YFLogxK
U2 - 10.1007/s11814-013-0124-6
DO - 10.1007/s11814-013-0124-6
M3 - Article
VL - 30
SP - 1836
EP - 1842
JO - Korean Journal of Chemical Engineering
JF - Korean Journal of Chemical Engineering
SN - 0256-1115
IS - 10
ER -