Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

Dae-Sung Kim, P. Joel Ross, Kirill Zaslavsky, James Ellis

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder characterized by deficits in social communication, and restricted and repetitive patterns of behavior. Despite its high prevalence, discovery of pathophysiological mechanisms underlying ASD has lagged due to a lack of appropriate model systems. Recent advances in induced pluripotent stem cell (iPSC) technology and neural differentiation techniques allow for detailed functional analyses of neurons generated from living individuals with ASD. Refinement of cortical neuron differentiation methods from iPSCs will enable mechanistic studies of specific neuronal subpopulations that may be preferentially impaired in ASD. In this review, we summarize recent accomplishments in differentiation of cortical neurons from human pluripotent stems cells and efforts to establish in vitro model systems to study ASD using personalized neurons.

Original languageEnglish
Article number109
JournalFrontiers in Cellular Neuroscience
Volume8
Issue number1 APR
DOIs
Publication statusPublished - 2014 Apr 11
Externally publishedYes

Fingerprint

Induced Pluripotent Stem Cells
Neurons
Pluripotent Stem Cells
Communication
Autism Spectrum Disorder
Technology

Keywords

  • Autism Spectrum Disorders (ASD)
  • Cellular phenotype
  • Disease modeling
  • Human pluripotent stem cells
  • Neocortical neurons
  • Neural differentiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. / Kim, Dae-Sung; Joel Ross, P.; Zaslavsky, Kirill; Ellis, James.

In: Frontiers in Cellular Neuroscience, Vol. 8, No. 1 APR, 109, 11.04.2014.

Research output: Contribution to journalReview article

Kim, Dae-Sung ; Joel Ross, P. ; Zaslavsky, Kirill ; Ellis, James. / Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. In: Frontiers in Cellular Neuroscience. 2014 ; Vol. 8, No. 1 APR.
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