Optimizing the circuit of a pulsatile extracorporeal life support system in terms of energy equivalent pressure and surplus hemodynamic energy

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The nonpulsatile blood flow obtained using standard cardiopulmonary bypass (CPB) circuits is still generally considered an acceptable, nonphysiologic compromise with few disadvantages. However, numerous reports have concluded that pulsatile perfusion during CPB achieves better multiorgan response postoperatively. Furthermore, pulsatile flow during CPB has been consistently recommended in pediatric and high-risk patients. However, most (80%) of the total hemodynamic energy generated by a pulsatile pump is absorbed by the components of the extracorporeal circuit and only a small portion of the pulsatile energy is delivered to the patient. Therefore, we considered that optimizations of CPB unit and extracorporeal life support (ECLS) system circuit components were needed to deliver sufficient pulsatile flow. In addition, energy equivalent pressure, surplus hemodynamic energy, and total hemodynamic energy, calculated using pressure and flow waveforms, were used to evaluate the pulsatilities of pulsatile CPB and ECLS systems.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalArtificial Organs
Volume33
Issue number11
DOIs
Publication statusPublished - 2009 Nov 1

Fingerprint

Life Support Systems
Extracorporeal Membrane Oxygenation
Hemodynamics
Cardiopulmonary Bypass
Pulsatile flow
Pulsatile Flow
Pressure
Networks (circuits)
Pediatrics
Blood
Pumps

Keywords

  • Energy equivalent pressure
  • Nonpulsatile
  • Pulsatile
  • Surplus hemodynamic energy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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title = "Optimizing the circuit of a pulsatile extracorporeal life support system in terms of energy equivalent pressure and surplus hemodynamic energy",
abstract = "The nonpulsatile blood flow obtained using standard cardiopulmonary bypass (CPB) circuits is still generally considered an acceptable, nonphysiologic compromise with few disadvantages. However, numerous reports have concluded that pulsatile perfusion during CPB achieves better multiorgan response postoperatively. Furthermore, pulsatile flow during CPB has been consistently recommended in pediatric and high-risk patients. However, most (80{\%}) of the total hemodynamic energy generated by a pulsatile pump is absorbed by the components of the extracorporeal circuit and only a small portion of the pulsatile energy is delivered to the patient. Therefore, we considered that optimizations of CPB unit and extracorporeal life support (ECLS) system circuit components were needed to deliver sufficient pulsatile flow. In addition, energy equivalent pressure, surplus hemodynamic energy, and total hemodynamic energy, calculated using pressure and flow waveforms, were used to evaluate the pulsatilities of pulsatile CPB and ECLS systems.",
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author = "Lim, {Choon Hak} and Sung Yang and Choi, {Jae Wook} and Kyung Sun",
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TY - JOUR

T1 - Optimizing the circuit of a pulsatile extracorporeal life support system in terms of energy equivalent pressure and surplus hemodynamic energy

AU - Lim, Choon Hak

AU - Yang, Sung

AU - Choi, Jae Wook

AU - Sun, Kyung

PY - 2009/11/1

Y1 - 2009/11/1

N2 - The nonpulsatile blood flow obtained using standard cardiopulmonary bypass (CPB) circuits is still generally considered an acceptable, nonphysiologic compromise with few disadvantages. However, numerous reports have concluded that pulsatile perfusion during CPB achieves better multiorgan response postoperatively. Furthermore, pulsatile flow during CPB has been consistently recommended in pediatric and high-risk patients. However, most (80%) of the total hemodynamic energy generated by a pulsatile pump is absorbed by the components of the extracorporeal circuit and only a small portion of the pulsatile energy is delivered to the patient. Therefore, we considered that optimizations of CPB unit and extracorporeal life support (ECLS) system circuit components were needed to deliver sufficient pulsatile flow. In addition, energy equivalent pressure, surplus hemodynamic energy, and total hemodynamic energy, calculated using pressure and flow waveforms, were used to evaluate the pulsatilities of pulsatile CPB and ECLS systems.

AB - The nonpulsatile blood flow obtained using standard cardiopulmonary bypass (CPB) circuits is still generally considered an acceptable, nonphysiologic compromise with few disadvantages. However, numerous reports have concluded that pulsatile perfusion during CPB achieves better multiorgan response postoperatively. Furthermore, pulsatile flow during CPB has been consistently recommended in pediatric and high-risk patients. However, most (80%) of the total hemodynamic energy generated by a pulsatile pump is absorbed by the components of the extracorporeal circuit and only a small portion of the pulsatile energy is delivered to the patient. Therefore, we considered that optimizations of CPB unit and extracorporeal life support (ECLS) system circuit components were needed to deliver sufficient pulsatile flow. In addition, energy equivalent pressure, surplus hemodynamic energy, and total hemodynamic energy, calculated using pressure and flow waveforms, were used to evaluate the pulsatilities of pulsatile CPB and ECLS systems.

KW - Energy equivalent pressure

KW - Nonpulsatile

KW - Pulsatile

KW - Surplus hemodynamic energy

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U2 - 10.1111/j.1525-1594.2009.00887.x

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