Optofluidic surface enhanced Raman scattering chip for detection of dengue virus

Suk Huh Yun, Aram J. Chung, Bernardo Cordovez, David Erickson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work we describe the development of an optofluidic device for surface enhanced Raman scattering (SERS) based detection of biological pathogens. The chip exploits the use of electro-active microwells which serve to both physically concentrate the Raman enhancers and to reduce the total analysis time through a unique electrokinetically driven on-chip mixing effect. To quantify the concentralion performance of the device we use 44 nm polystyrene particles at low electric field strength (between 1.00-2.00 V) and demonstrate close to 90% concentration saturation within 2.5 s. We demonstrate the mixing capability through the enhanced detection of dengue virus serotype 2 (DENV-2). With DENV-2, we successfully detected the SERS signals with a limit of detection of 30 pM.

Original languageEnglish
Title of host publication2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008
Pages873-876
Number of pages4
EditionPART B
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008 - Boston, MA, United States
Duration: 2008 Oct 312008 Nov 6

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings
NumberPART B
Volume13

Other

Other2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008
CountryUnited States
CityBoston, MA
Period08/10/3108/11/6

ASJC Scopus subject areas

  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Optofluidic surface enhanced Raman scattering chip for detection of dengue virus'. Together they form a unique fingerprint.

  • Cite this

    Yun, S. H., Chung, A. J., Cordovez, B., & Erickson, D. (2009). Optofluidic surface enhanced Raman scattering chip for detection of dengue virus. In 2008 Proceedings of ASME International Mechanical Engineering Congress and Exposition, IMECE 2008 (PART B ed., pp. 873-876). (ASME International Mechanical Engineering Congress and Exposition, Proceedings; Vol. 13, No. PART B). https://doi.org/10.1115/IMECE2008-67243