Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization

Shelly Sooyun Song, Byeong Jun Kang, Hyo Jin Lee, Hye Ri Sim, Tae Hyong Kim, Sehyoun Yoon, Bongjune Yoon, Ja-Hyun Baik, Lei Wen, George J. Augustine, Lei Wen, George J. Augustine, Lei Wen, George J. Augustine

Research output: Contribution to journalArticle

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Abstract

Long-lasting, drug-induced adaptations within the nucleus accumbens (NAc) have been proposed to contribute to drug-mediated addictive behaviors. Here we have used an optogenetic approach to examine the role of NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2Rs) in cocaine-induced behavioral sensitization. Adeno-associated viral vectors encoding channelrhodopsin-2 (ChR2) were delivered into the NAc of D2R-Cre transgenic mice. This allowed us to selectively photostimulate D2R-MSNs in NAc. D2R-MSNs form local inhibitory circuits, because photostimulation of D2R-MSN evoked inhibitory postsynaptic currents (IPSCs) in neighboring MSNs. Photostimulation of NAc D2R-MSN in vivo affected neither the initiation nor the expression of cocaine-induced behavioral sensitization. However, photostimulation during the drug withdrawal period attenuated expression of cocaine-induced behavioral sensitization. These results show that D2R-MSNs of NAc play a key role in withdrawal-induced plasticity and may contribute to relapse after cessation of drug abuse.

Original languageEnglish
Article number336
Pages (from-to)1-11
Number of pages11
JournalFrontiers in Behavioral Neuroscience
Volume8
Issue numberOCT
DOIs
Publication statusPublished - 2014 Oct 13

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Optogenetics
Dopamine D2 Receptors
Cocaine
Nucleus Accumbens
Neurons
Pharmaceutical Preparations
Addictive Behavior
Inhibitory Postsynaptic Potentials
Transgenic Mice
Substance-Related Disorders
Recurrence

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. / Song, Shelly Sooyun; Kang, Byeong Jun; Lee, Hyo Jin; Sim, Hye Ri; Kim, Tae Hyong; Yoon, Sehyoun; Yoon, Bongjune; Baik, Ja-Hyun; Wen, Lei; Augustine, George J.; Wen, Lei; Augustine, George J.; Wen, Lei; Augustine, George J.

In: Frontiers in Behavioral Neuroscience, Vol. 8, No. OCT, 336, 13.10.2014, p. 1-11.

Research output: Contribution to journalArticle

Song, SS, Kang, BJ, Lee, HJ, Sim, HR, Kim, TH, Yoon, S, Yoon, B, Baik, J-H, Wen, L, Augustine, GJ, Wen, L, Augustine, GJ, Wen, L & Augustine, GJ 2014, 'Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization', Frontiers in Behavioral Neuroscience, vol. 8, no. OCT, 336, pp. 1-11. https://doi.org/10.3389/fnbeh.2014.00336
Song, Shelly Sooyun ; Kang, Byeong Jun ; Lee, Hyo Jin ; Sim, Hye Ri ; Kim, Tae Hyong ; Yoon, Sehyoun ; Yoon, Bongjune ; Baik, Ja-Hyun ; Wen, Lei ; Augustine, George J. ; Wen, Lei ; Augustine, George J. ; Wen, Lei ; Augustine, George J. / Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. In: Frontiers in Behavioral Neuroscience. 2014 ; Vol. 8, No. OCT. pp. 1-11.
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