Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice

Su J. Lee, Seung Geun Oh, Sang W. Seo, Hyun Jong Ahn, Dongho Geum, Jeong J. Cho, Cheung Seog Park

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Abstract

Epicutaneously administered chemical antigens like 2,4-dinitrofluorobenzene (DNFB), evoke an atopic dermatitis (AD)-like dermatitis reaction in NC/Nga mice under specific pathogen free (SPF) conditions. Astragalus membranaceus (AM), is a popular herbal medicine used to treat allergic diseases in East Asia. In the present study, we examined whether AM suppress AD-like skin lesions in NC/Nga mice treated with DNFB under SPF conditions. Oral administration of AM to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Moreover, IFN-γ production by CD4 + T cells from the lymph nodes of DNFB-treated NC/Nga mice was significantly inhibited by AM treatment, although levels of IL-4 and total IgE in serum were not. Study findings suggest that AM may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ production.

Original languageEnglish
Pages (from-to)1468-1471
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number8
DOIs
Publication statusPublished - 2007 Aug 1

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Keywords

  • 2,4-dinitrofluorobenzene (DNFB)
  • Astragalus membranaceus
  • Atopic dermatitis
  • NC/Nga mice

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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