Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice

S. P. Choi, H. N. Oh, C. Y. Choi, H. Ahn, H. S. Yun, Y. M. Chung, B. Kim, S. J. Lee, Taehoon Chun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis. Methods and Results: Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ) and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice. Conclusion: Oral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response. Significance and Impact of the Study: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalJournal of Applied Microbiology
Volume124
Issue number3
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Lactobacillus plantarum
Betula
Pollen
Oral Administration
Interleukin-13
Interleukin-5
Interleukin-4
Cell Count
Serum
Th1-Th2 Balance
Cytokines
Nasal Cavity
Bronchoalveolar Lavage Fluid
Probiotics
Therapeutic Uses
Immunoglobulin E
Allergic Rhinitis
Animal Models
Immunoglobulin G
Lymph Nodes

Keywords

  • allergic rhinitis
  • birch pollen
  • CJLP133
  • CJLP243
  • Lactobacillus plantarum

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice. / Choi, S. P.; Oh, H. N.; Choi, C. Y.; Ahn, H.; Yun, H. S.; Chung, Y. M.; Kim, B.; Lee, S. J.; Chun, Taehoon.

In: Journal of Applied Microbiology, Vol. 124, No. 3, 01.03.2018, p. 821-828.

Research output: Contribution to journalArticle

Choi, S. P. ; Oh, H. N. ; Choi, C. Y. ; Ahn, H. ; Yun, H. S. ; Chung, Y. M. ; Kim, B. ; Lee, S. J. ; Chun, Taehoon. / Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice. In: Journal of Applied Microbiology. 2018 ; Vol. 124, No. 3. pp. 821-828.
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AU - Choi, S. P.

AU - Oh, H. N.

AU - Choi, C. Y.

AU - Ahn, H.

AU - Yun, H. S.

AU - Chung, Y. M.

AU - Kim, B.

AU - Lee, S. J.

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AB - Aims: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis. Methods and Results: Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ) and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice. Conclusion: Oral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response. Significance and Impact of the Study: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model.

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