Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model

Sun Hee JANG, Jisang PARK, Sae Hae KIM, Kyung Min CHOI, Eun Sil KO, Jeong Dan CHA, Young Ran LEE, Hyon Seok Jang, Yong Suk JANG

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Red ginseng is a well-known alternative medicine with anti-inflammatory activity. It exerts pharmacological effects through the transformation of saponin into metabolites by intestinal microbiota. Given that intestinal microflora vary among individuals, the pharmacological effects of red ginseng likely vary among individuals. In order to produce homogeneously effective red ginseng, we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium (DSS)-induced colitis model in mice. Initial analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis, compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics only. Subsequent analysis of the levels of serum IL-6 and TNF-α, inflammatory biomarkers that are increased at the initiation stage of colitis, were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control group. The levels of inflammatory cytokines and mRNAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated groups. Collectively, oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model, suggesting that it can be used as a uniformly effective red ginseng product.

Original languageEnglish
Pages (from-to)192-201
Number of pages10
JournalChinese Journal of Natural Medicines
Volume15
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

Fingerprint

Dextran Sulfate
Panax
Probiotics
Colitis
Powders
Oral Administration
Pharmacology
Saponins
Complementary Therapies
Interleukin-6
Anti-Inflammatory Agents
Biomarkers
Cytokines
Control Groups
Messenger RNA

Keywords

  • Colitis
  • Fermentation
  • Inflammation
  • Probiotics
  • Red ginseng

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model. / JANG, Sun Hee; PARK, Jisang; KIM, Sae Hae; CHOI, Kyung Min; KO, Eun Sil; CHA, Jeong Dan; LEE, Young Ran; Jang, Hyon Seok; JANG, Yong Suk.

In: Chinese Journal of Natural Medicines, Vol. 15, No. 3, 01.03.2017, p. 192-201.

Research output: Contribution to journalArticle

JANG, Sun Hee ; PARK, Jisang ; KIM, Sae Hae ; CHOI, Kyung Min ; KO, Eun Sil ; CHA, Jeong Dan ; LEE, Young Ran ; Jang, Hyon Seok ; JANG, Yong Suk. / Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model. In: Chinese Journal of Natural Medicines. 2017 ; Vol. 15, No. 3. pp. 192-201.
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