Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model

Sun Hee JANG, Jisang PARK, Sae Hae KIM, Kyung Min CHOI, Eun Sil KO, Jeong Dan CHA, Young Ran LEE, Hyon Seok Jang, Yong Suk JANG

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Red ginseng is a well-known alternative medicine with anti-inflammatory activity. It exerts pharmacological effects through the transformation of saponin into metabolites by intestinal microbiota. Given that intestinal microflora vary among individuals, the pharmacological effects of red ginseng likely vary among individuals. In order to produce homogeneously effective red ginseng, we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium (DSS)-induced colitis model in mice. Initial analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis, compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics only. Subsequent analysis of the levels of serum IL-6 and TNF-α, inflammatory biomarkers that are increased at the initiation stage of colitis, were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control group. The levels of inflammatory cytokines and mRNAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated groups. Collectively, oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model, suggesting that it can be used as a uniformly effective red ginseng product.

    Original languageEnglish
    Pages (from-to)192-201
    Number of pages10
    JournalChinese Journal of Natural Medicines
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - 2017 Mar 1

    Keywords

    • Colitis
    • Fermentation
    • Inflammation
    • Probiotics
    • Red ginseng

    ASJC Scopus subject areas

    • Drug Discovery
    • Complementary and alternative medicine

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