Oral muscle relaxant may induce immediate allergic reactions

Gyu Young Hur, Eui Kyung Hwang, Jae Young Moon, Young Min Ye, Jae Jeong Shim, Hae Sim Park, Kyung Ho Kang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Eperisone and afloqualone act by relaxing both skeletal and vascular smooth muscles to improve circulation and suppress pain reflex. These drugs are typically prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) as painkillers. However, there have been no reports on serious adverse reactions to oral muscle relaxants; and this is the first report to describe three allergic reactions caused by eperisone and afloqualone. All three patients had histories of allergic reactions after oral intake of multiple painkillers, including oral muscle relaxants and NSAIDs, for chronic muscle pain. An open-label oral challenge test was performed with each drug to confirm which drugs caused the systemic reactions. All patients experienced the same reactions within one hour after oral intake of eperisone or afloqualone. The severity of these reactions ranged from laryngeal edema to hypotension. To confirm that the systemic reaction was caused by eperisone or afloqualone, skin prick testing and intradermal skin tests were performed with eperisone or afloqualone extract in vivo, and basophil activity tests were performed after stimulation with these drugs in vitro. In one patient with laryngeal edema, the intradermal test with afloqualone extract had a positive result, and CD63 expression levels on basophils increased in a dose-dependent manner by stimulation with afloqualone. We report three allergic reactions caused by oral muscle relaxants that might be mediated by non-immunoglobulin E-mediated responses. Since oral muscle relaxants such as eperisone and afloqualone are commonly prescribed for chronic muscle pain and can induce severe allergic reactions, we should prescribe them carefully.

Original languageEnglish
Pages (from-to)863-865
Number of pages3
JournalYonsei Medical Journal
Volume53
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Hypersensitivity
Muscles
Laryngeal Edema
Pharmaceutical Preparations
Intradermal Tests
Basophils
Myalgia
Chronic Pain
Anti-Inflammatory Agents
afloqualone
Skin Tests
Vascular Smooth Muscle
Hypotension
Reflex
eperisone
Pain
Skin

Keywords

  • Anaphylaxis
  • Basophil activation
  • Muscle relaxant
  • Oral provocation test

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oral muscle relaxant may induce immediate allergic reactions. / Hur, Gyu Young; Hwang, Eui Kyung; Moon, Jae Young; Ye, Young Min; Shim, Jae Jeong; Park, Hae Sim; Kang, Kyung Ho.

In: Yonsei Medical Journal, Vol. 53, No. 4, 01.07.2012, p. 863-865.

Research output: Contribution to journalArticle

Hur, Gyu Young ; Hwang, Eui Kyung ; Moon, Jae Young ; Ye, Young Min ; Shim, Jae Jeong ; Park, Hae Sim ; Kang, Kyung Ho. / Oral muscle relaxant may induce immediate allergic reactions. In: Yonsei Medical Journal. 2012 ; Vol. 53, No. 4. pp. 863-865.
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