Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors

Hye Seung Chung, Jae Gon Kim, Jae Won Kim, Hyung Wook Kim, Bongjune Yoon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalRegulatory Peptides
Volume194-195
DOIs
Publication statusPublished - 2014 Nov 1

Fingerprint

Emotions
Antidepressive Agents
Brain
Septal Nuclei
Animals
Interpersonal Relations
Arousal
Reward
Hypothalamus
Sleep
Orexins
Anxiety
Processing

Keywords

  • Anxiety
  • Orexin
  • Social defeat stress
  • Stress susceptibility

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors. / Chung, Hye Seung; Kim, Jae Gon; Kim, Jae Won; Kim, Hyung Wook; Yoon, Bongjune.

In: Regulatory Peptides, Vol. 194-195, 01.11.2014, p. 16-22.

Research output: Contribution to journalArticle

Chung, Hye Seung ; Kim, Jae Gon ; Kim, Jae Won ; Kim, Hyung Wook ; Yoon, Bongjune. / Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors. In: Regulatory Peptides. 2014 ; Vol. 194-195. pp. 16-22.
@article{a8cc101c27aa445dbfec78ea574d27f1,
title = "Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors",
abstract = "Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in na{\"i}ve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.",
keywords = "Anxiety, Orexin, Social defeat stress, Stress susceptibility",
author = "Chung, {Hye Seung} and Kim, {Jae Gon} and Kim, {Jae Won} and Kim, {Hyung Wook} and Bongjune Yoon",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.regpep.2014.11.003",
language = "English",
volume = "194-195",
pages = "16--22",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",

}

TY - JOUR

T1 - Orexin administration to mice that underwent chronic stress produces bimodal effects on emotion-related behaviors

AU - Chung, Hye Seung

AU - Kim, Jae Gon

AU - Kim, Jae Won

AU - Kim, Hyung Wook

AU - Yoon, Bongjune

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.

AB - Orexin plays diverse roles in regulating behaviors, such as sleep and wake, reward processing, arousal, and stress and anxiety. The orexin system may accomplish these multiple tasks through its complex innervations throughout the brain. The emerging evidence indicates a role of orexin in emotional behaviors; however, most of the previous studies have investigated the function of orexin in naïve animals. Here, we examined a functional role of orexin in mice that had been exposed to repeated stress. Chronic social defeat stress produced differential social interaction behaviors in mice (susceptible versus resilient) and these two groups of mice displayed different levels of prepro-orexin in the hypothalamus. Exogenously added orexin A to the brain induced an antidepressant-like effect in only the susceptible mice but not in the resilient mice. In contrast, orexin A and orexin B infused together produced an anxiogenic effect in only the resilient mice and not in the susceptible mice. Furthermore, we found that the antidepressant-like effect of orexin A is mediated by the bed nucleus of the stria terminalis (BNST) after exposure to chronic restraint stress. These findings reveal a bimodal effect of the orexin system in regulating emotional behavior that depends on stress susceptibility.

KW - Anxiety

KW - Orexin

KW - Social defeat stress

KW - Stress susceptibility

UR - http://www.scopus.com/inward/record.url?scp=84921343968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921343968&partnerID=8YFLogxK

U2 - 10.1016/j.regpep.2014.11.003

DO - 10.1016/j.regpep.2014.11.003

M3 - Article

C2 - 25450574

AN - SCOPUS:84921343968

VL - 194-195

SP - 16

EP - 22

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

ER -