Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading

Yun Hak Lee, Nayoung Park, Young Bin Park, Yu Jeong Hwang, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Two novel Cu2+ sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu2+ sensing. The ER-selective Cu2+ sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.

Original languageEnglish
Pages (from-to)3197-3200
Number of pages4
JournalChemical Communications
Volume50
Issue number24
DOIs
Publication statusPublished - 2014 Feb 25

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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